USS Radford (DD-446), named for Rear Admiral William Radford, was a Fletcher-class destroyer in the United States Navy. Entering service in 1942 during World War II the ship also saw action during the Korean War and the Vietnam War. The ship was removed from service in 1969 and sold for scrap in 1970.

William Radford was a rear admiral of the United States Navy who served during the Mexican–American War and the American Civil War, in which he remained loyal to the Union, despite his Virginia birth. Radford commanded the Ironclad Division in the attacks on Fort Fisher to assert Union control of Cape Fear.