Iatrogenesis refers to any effect on a person, resulting from any activity of one or more other persons acting as healthcare professionals or promoting products or services as beneficial to health, which does not support a goal of the person affected. While some have advocated using the term to refer to all "events caused by the health care delivery team", whether "positive or negative", consensus limits use of iatrogenesis to adverse effects, including all adverse unforeseen outcomes resulting from medication or other medical treatment or intervention; some iatrogenic effects are defined and recognized, such as a complication following a surgical procedure. Cases of iatrogenesis may include: complications arising from a medical procedure or treatment side effects of possible drug interactions medical errors negligence use of contaminated instruments anxiety or annoyance in the patient, physician or treatment provider in relation to medical procedures or treatments unnecessary medical treatment resulting from a physician's decisionUnlike an adverse event, an iatrogenic effect is not always harmful.
For example, a scar created by surgery is said to be iatrogenic though it does not represent improper care and may not be troublesome. Professionals who may cause iatrogenic harm to patients include physicians, nurses, psychologists, medical laboratory scientists and therapists. Iatrogenesis can result from complementary and alternative medicine treatments. Globally, as of 2013, an estimated 20 million negative effects from treatment occurred, it is estimated that 142,000 people died in 2013 from adverse effects of medical treatment, up from 94,000 in 1990. Risk associated with medical interventions Adverse effects of prescription drugs Overuse of drugs Prescription drug interaction Medical errors Incorrect prescription due to illegible handwriting or computer typos Faulty procedures, information, methods, or equipment Negligence Nosocomial infections Iatrogenic conditions do not result from medical errors, such as mistakes made in surgery, or the prescription or dispensing of the wrong therapy, such as a drug.
In fact and sometimes adverse effects of a medical treatment are iatrogenic. For example, radiation therapy and chemotherapy — aggressive for therapeutic effect — produce such iatrogenic effects as hair loss, hemolytic anemia, diabetes insipidus, nausea, brain damage, infertility, etc; the loss of function resulting from the required removal of a diseased organ is iatrogenic, as in the case of diabetes consequential to the removal of all or part of the pancreas. The incidence of iatrogenesis may be misleading in some cases. For example, ruptured aortic aneurysm is fatal in most cases. Patients who die during or after an operation will still be considered iatrogenic deaths, but the procedure itself remains a better bet than the 100% probability of death if left untreated. Other situations may involve actual negligence or faulty procedures, such as when pharmacotherapists produce handwritten prescriptions for drugs. A common iatrogenic effect is caused by drug interaction, i.e. when pharmacotherapists fail to check for all medications a patient is taking and prescribe new ones that interact agonistically or antagonistically.
Such situations can cause significant mortality. Adverse reactions, such as allergic reactions to drugs when unexpected by pharmacotherapists, are classified as iatrogenic; the evolution of antibiotic resistance in bacteria is iatrogenic as well. Bacterial strains resistant to antibiotics have evolved in response to the overprescription of antibiotic drugs. Certain drugs are toxic in their own right in therapeutic doses because of their mechanism of action. Alkylating antineoplastic agents, for example, cause DNA damage, more harmful to cancer cells than regular cells. However, alkylation causes severe side-effects and is carcinogenic in its own right, with potential to lead to the development of secondary tumors. In a similar manner, arsenic-based medications like melarsoprol, used to treat trypanosomiasis, can cause arsenic poisoning. Adverse effects can appear mechanically; the design of some surgical instruments may be decades old, hence certain adverse effects may never have been properly cauterized.
In psychiatry, iatrogenesis can occur due to misdiagnosis. An example of a iatrogenic condition due to common misdiagnosis is bipolar disorder in pediatric patients. Other conditions such as somatoform disorder and chronic fatigue syndrome are theorized to have significant sociocultural and iatrogenic components. Posttraumatic stress disorder is hypothesized to be prone to iatrogenic complications based on treatment modality; the psychiatric treatment of some conditions and populations, such as substance abuse, antisocial youths are regarded as carrying significant risks for iatrogenesis. At the other end of the spectrum, dissociative identity disorder is considered by a minority of theorists to be a wholly iatrogenic disorder with the bulk of diagnoses arising from a tiny fraction of practitioners; the degree of association of any particular condition with iatrogenesis is unclear and in some cases controversial. The over-dia
International Standard Serial Number
An International Standard Serial Number is an eight-digit serial number used to uniquely identify a serial publication, such as a magazine. The ISSN is helpful in distinguishing between serials with the same title. ISSN are used in ordering, interlibrary loans, other practices in connection with serial literature; the ISSN system was first drafted as an International Organization for Standardization international standard in 1971 and published as ISO 3297 in 1975. ISO subcommittee TC 46/SC 9 is responsible for maintaining the standard; when a serial with the same content is published in more than one media type, a different ISSN is assigned to each media type. For example, many serials are published both in electronic media; the ISSN system refers to these types as electronic ISSN, respectively. Conversely, as defined in ISO 3297:2007, every serial in the ISSN system is assigned a linking ISSN the same as the ISSN assigned to the serial in its first published medium, which links together all ISSNs assigned to the serial in every medium.
The format of the ISSN is an eight digit code, divided by a hyphen into two four-digit numbers. As an integer number, it can be represented by the first seven digits; the last code digit, which may be 0-9 or an X, is a check digit. Formally, the general form of the ISSN code can be expressed as follows: NNNN-NNNC where N is in the set, a digit character, C is in; the ISSN of the journal Hearing Research, for example, is 0378-5955, where the final 5 is the check digit, C=5. To calculate the check digit, the following algorithm may be used: Calculate the sum of the first seven digits of the ISSN multiplied by its position in the number, counting from the right—that is, 8, 7, 6, 5, 4, 3, 2, respectively: 0 ⋅ 8 + 3 ⋅ 7 + 7 ⋅ 6 + 8 ⋅ 5 + 5 ⋅ 4 + 9 ⋅ 3 + 5 ⋅ 2 = 0 + 21 + 42 + 40 + 20 + 27 + 10 = 160 The modulus 11 of this sum is calculated. For calculations, an upper case X in the check digit position indicates a check digit of 10. To confirm the check digit, calculate the sum of all eight digits of the ISSN multiplied by its position in the number, counting from the right.
The modulus 11 of the sum must be 0. There is an online ISSN checker. ISSN codes are assigned by a network of ISSN National Centres located at national libraries and coordinated by the ISSN International Centre based in Paris; the International Centre is an intergovernmental organization created in 1974 through an agreement between UNESCO and the French government. The International Centre maintains a database of all ISSNs assigned worldwide, the ISDS Register otherwise known as the ISSN Register. At the end of 2016, the ISSN Register contained records for 1,943,572 items. ISSN and ISBN codes are similar in concept. An ISBN might be assigned for particular issues of a serial, in addition to the ISSN code for the serial as a whole. An ISSN, unlike the ISBN code, is an anonymous identifier associated with a serial title, containing no information as to the publisher or its location. For this reason a new ISSN is assigned to a serial each time it undergoes a major title change. Since the ISSN applies to an entire serial a new identifier, the Serial Item and Contribution Identifier, was built on top of it to allow references to specific volumes, articles, or other identifiable components.
Separate ISSNs are needed for serials in different media. Thus, the print and electronic media versions of a serial need separate ISSNs. A CD-ROM version and a web version of a serial require different ISSNs since two different media are involved. However, the same ISSN can be used for different file formats of the same online serial; this "media-oriented identification" of serials made sense in the 1970s. In the 1990s and onward, with personal computers, better screens, the Web, it makes sense to consider only content, independent of media; this "content-oriented identification" of serials was a repressed demand during a decade, but no ISSN update or initiative occurred. A natural extension for ISSN, the unique-identification of the articles in the serials, was the main demand application. An alternative serials' contents model arrived with the indecs Content Model and its application, the digital object identifier, as ISSN-independent initiative, consolidated in the 2000s. Only in 2007, ISSN-L was defined in the
Organs are groups of tissues with similar functions. Plant and animal life relies on many organs. Organs are composed of main tissue, "sporadic" tissues, stroma; the main tissue is that, unique for the specific organ, such as the myocardium, the main tissue of the heart, while sporadic tissues include the nerves, blood vessels, connective tissues. The main tissues that make up an organ tend to have common embryologic origins, such as arising from the same germ layer. Functionally-related organs cooperate to form whole organ systems. Organs exist in most multicellular organisms. In single-celled organisms such as bacteria, the functional analogue of an organ is known as an organelle. In plants there are three main organs. A hollow organ is an internal organ that forms a hollow tube, or pouch such as the stomach, intestine, or bladder. In the study of anatomy, the term viscus is used to refer to an internal organ, viscera is the plural form. 79 organs have been identified in the human body. In biology, tissue is a cellular organizational level between complete organs.
A tissue is an ensemble of similar cells and their extracellular matrix from the same origin that together carry out a specific function. Organs are formed by the functional grouping together of multiple tissues; the study of human and animal tissues is known as histology or, in connection with disease, histopathology. For plants, the discipline is called plant morphology. Classical tools for studying tissues include the paraffin block in which tissue is embedded and sectioned, the histological stain, the optical microscope. In the last couple of decades, developments in electron microscopy, immunofluorescence, the use of frozen tissue sections have enhanced the detail that can be observed in tissues. With these tools, the classical appearances of tissues can be examined in health and disease, enabling considerable refinement of medical diagnosis and prognosis. Two or more organs working together in the execution of a specific body function form an organ system called a biological system or body system.
The functions of organ systems share significant overlap. For instance, the nervous and endocrine system both operate via the hypothalamus. For this reason, the two systems are studied as the neuroendocrine system; the same is true for the musculoskeletal system because of the relationship between the muscular and skeletal systems. Common organ system designations in plants includes the differentiation of root. All parts of the plant above ground, including the functionally distinct leaf and flower organs, may be classified together as the shoot organ system. Animals such as humans have a variety of organ systems; these specific systems are widely studied in human anatomy. Cardiovascular system: pumping and channeling blood to and from the body and lungs with heart and blood vessels. Digestive system: digestion and processing food with salivary glands, stomach, gallbladder, intestines, colon and anus. Endocrine system: communication within the body using hormones made by endocrine glands such as the hypothalamus, pituitary gland, pineal body or pineal gland, thyroid and adrenals, i.e. adrenal glands.
Excretory system: kidneys, ureters and urethra involved in fluid balance, electrolyte balance and excretion of urine. Lymphatic system: structures involved in the transfer of lymph between tissues and the blood stream, the lymph and the nodes and vessels that transport it including the Immune system: defending against disease-causing agents with leukocytes, adenoids and spleen. Integumentary system: skin and nails of mammals. Scales of fish and birds, feathers of birds. Muscular system: movement with muscles. Nervous system: collecting and processing information with brain, spinal cord and nerves. Reproductive system: the sex organs, such as ovaries, fallopian tubes, vulva, testes, vas deferens, seminal vesicles and penis. Respiratory system: the organs used for breathing, the pharynx, trachea, bronchi and diaphragm. Skeletal system: structural support and protection with bones, cartilage and tendons; the study of plant organs is referred to as plant morphology, rather than anatomy – as in animal systems.
Organs of plants can be divided into reproductive. Vegetative plant organs include roots and leaves; the reproductive organs are variable. In flowering plants, they are represented by the flower and fruit. In conifers, the organ that bears the reproductive structures is called a cone. In other divisions of plants, the reproductive organs are called strobili, in Lycopodiophyta, or gametophores in mosses; the vegetative organs are essential for maintaining the life of a plant. While there can be 11 organ systems in animals, there are far fewer in plants, where some perform the vital functions, such as photosynthesis, while the reproductive organs are essential in reproduction. However, if there is asexual vegetative reproduction, the vegetative organs are those that create the new generation of plants. Many societies have a system for organ donation, in which a living or deceased donor's organ is transplanted into a person with a failing organ; the transplantation of larger solid organs requires immunosuppression to prevent organ rejection or graft-versus-host disease.
There is considerable interest throughout the world in creating laboratory-grown or artificial organs. The English word "organ" dates back in reference to any musical instrument. By the late 14th
Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, is a protective response involving immune cells, blood vessels, molecular mediators. The function of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory process, initiate tissue repair; the five classical signs of inflammation are heat, redness and loss of function. Inflammation is a generic response, therefore it is considered as a mechanism of innate immunity, as compared to adaptive immunity, specific for each pathogen. Too little inflammation could lead to progressive tissue destruction by the harmful stimulus and compromise the survival of the organism. In contrast, chronic inflammation may lead to a host of diseases, such as hay fever, atherosclerosis, rheumatoid arthritis, cancer. Inflammation is therefore closely regulated by the body. Inflammation can be classified as either chronic.
Acute inflammation is the initial response of the body to harmful stimuli and is achieved by the increased movement of plasma and leukocytes from the blood into the injured tissues. A series of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, various cells within the injured tissue. Prolonged inflammation, known as chronic inflammation, leads to a progressive shift in the type of cells present at the site of inflammation, such as mononuclear cells, is characterized by simultaneous destruction and healing of the tissue from the inflammatory process. Inflammation is not a synonym for infection. Infection describes the interaction between the action of microbial invasion and the reaction of the body's inflammatory response—the two components are considered together when discussing an infection, the word is used to imply a microbial invasive cause for the observed inflammatory reaction. Inflammation on the other hand describes purely the body's immunovascular response, whatever the cause may be.
But because of how the two are correlated, words ending in the suffix -itis are sometimes informally described as referring to infection. For example, the word urethritis means only "urethral inflammation", but clinical health care providers discuss urethritis as a urethral infection because urethral microbial invasion is the most common cause of urethritis, it is useful to differentiate inflammation and infection because there are typical situations in pathology and medical diagnosis where inflammation is not driven by microbial invasion – for example, trauma and autoimmune diseases including type III hypersensitivity. Conversely, there is pathology where microbial invasion does not cause the classic inflammatory response – for example, parasitosis or eosinophilia. Acute inflammation is a short-term process appearing within a few minutes or hours and begins to cease upon the removal of the injurious stimulus, it involves a coordinated and systemic mobilization response locally of various immune and neurological mediators of acute inflammation.
In a normal healthy response, it becomes activated, clears the pathogen and begins a repair process and ceases. It is characterized by five cardinal signs:An acronym that may be used to remember the key symptoms is "PRISH", for pain, immobility and heat; the traditional names for signs of inflammation come from Latin: Dolor Calor Rubor Tumor Functio laesa The first four were described by Celsus, while loss of function was added by Galen. However, the addition of this fifth sign has been ascribed to Thomas Sydenham and Virchow. Redness and heat are due to increased blood flow at body core temperature to the inflamed site. Loss of function has multiple causes. Acute inflammation of the lung does not cause pain unless the inflammation involves the parietal pleura, which does have pain-sensitive nerve endings; the process of acute inflammation is initiated by resident immune cells present in the involved tissue resident macrophages, dendritic cells, Kupffer cells and mast cells. These cells possess surface receptors known as pattern recognition receptors, which recognize two subclasses of molecules: pathogen-associated molecular patterns and damage-associated molecular patterns.
PAMPs are compounds that are associated with various pathogens, but which are distinguishable from host molecules. DAMPs are compounds that are associated with host-related cell damage. At the onset of an infection, burn, or other injuries, these cells undergo activation and release inflammatory mediators responsible for the clinical signs of inflammation. Vasodilation and its resulting increased blood flow causes increased heat. Increased permeability of the blood vessels results in an exudation of plasma proteins and fluid into the tissue, which manifests itself as swelling; some of the released mediators such as bradykinin increase the sensitivity to pain. The mediator molecules alter the blood vessels to
OCLC Online Computer Library Center, Incorporated d/b/a OCLC is an American nonprofit cooperative organization "dedicated to the public purposes of furthering access to the world's information and reducing information costs". It was founded in 1967 as the Ohio College Library Center. OCLC and its member libraries cooperatively produce and maintain WorldCat, the largest online public access catalog in the world. OCLC is funded by the fees that libraries have to pay for its services. OCLC maintains the Dewey Decimal Classification system. OCLC began in 1967, as the Ohio College Library Center, through a collaboration of university presidents, vice presidents, library directors who wanted to create a cooperative computerized network for libraries in the state of Ohio; the group first met on July 5, 1967 on the campus of the Ohio State University to sign the articles of incorporation for the nonprofit organization, hired Frederick G. Kilgour, a former Yale University medical school librarian, to design the shared cataloging system.
Kilgour wished to merge the latest information storage and retrieval system of the time, the computer, with the oldest, the library. The plan was to merge the catalogs of Ohio libraries electronically through a computer network and database to streamline operations, control costs, increase efficiency in library management, bringing libraries together to cooperatively keep track of the world's information in order to best serve researchers and scholars; the first library to do online cataloging through OCLC was the Alden Library at Ohio University on August 26, 1971. This was the first online cataloging by any library worldwide. Membership in OCLC is based on use of services and contribution of data. Between 1967 and 1977, OCLC membership was limited to institutions in Ohio, but in 1978, a new governance structure was established that allowed institutions from other states to join. In 2002, the governance structure was again modified to accommodate participation from outside the United States.
As OCLC expanded services in the United States outside Ohio, it relied on establishing strategic partnerships with "networks", organizations that provided training and marketing services. By 2008, there were 15 independent United States regional service providers. OCLC networks played a key role in OCLC governance, with networks electing delegates to serve on the OCLC Members Council. During 2008, OCLC commissioned two studies to look at distribution channels. In early 2009, OCLC negotiated new contracts with the former networks and opened a centralized support center. OCLC provides bibliographic and full-text information to anyone. OCLC and its member libraries cooperatively produce and maintain WorldCat—the OCLC Online Union Catalog, the largest online public access catalog in the world. WorldCat has holding records from private libraries worldwide; the Open WorldCat program, launched in late 2003, exposed a subset of WorldCat records to Web users via popular Internet search and bookselling sites.
In October 2005, the OCLC technical staff began a wiki project, WikiD, allowing readers to add commentary and structured-field information associated with any WorldCat record. WikiD was phased out; the Online Computer Library Center acquired the trademark and copyrights associated with the Dewey Decimal Classification System when it bought Forest Press in 1988. A browser for books with their Dewey Decimal Classifications was available until July 2013; until August 2009, when it was sold to Backstage Library Works, OCLC owned a preservation microfilm and digitization operation called the OCLC Preservation Service Center, with its principal office in Bethlehem, Pennsylvania. The reference management service QuestionPoint provides libraries with tools to communicate with users; this around-the-clock reference service is provided by a cooperative of participating global libraries. Starting in 1971, OCLC produced catalog cards for members alongside its shared online catalog. OCLC commercially sells software, such as CONTENTdm for managing digital collections.
It offers the bibliographic discovery system WorldCat Discovery, which allows for library patrons to use a single search interface to access an institution's catalog, database subscriptions and more. OCLC has been conducting research for the library community for more than 30 years. In accordance with its mission, OCLC makes its research outcomes known through various publications; these publications, including journal articles, reports and presentations, are available through the organization's website. OCLC Publications – Research articles from various journals including Code4Lib Journal, OCLC Research, Reference & User Services Quarterly, College & Research Libraries News, Art Libraries Journal, National Education Association Newsletter; the most recent publications are displayed first, all archived resources, starting in 1970, are available. Membership Reports – A number of significant reports on topics ranging from virtual reference in libraries to perceptions about library funding. Newsletters – Current and archived newsletters for the library and archive community.
Presentations – Presentations from both guest speakers and OCLC research from conferences and other events. The presentations are organized into five categories: Conference presentations, Dewey presentations, Distinguished Seminar Series, Guest presentations, Research staff
Health, as defined by the World Health Organization, is "a state of complete physical and social well-being and not the absence of disease or infirmity." This definition has been subject to controversy. Health may be defined as the ability to adapt and manage physical and social challenges throughout life; the meaning of health has evolved over time. In keeping with the biomedical perspective, early definitions of health focused on the theme of the body's ability to function. An example of such a definition of health is: "a state characterized by anatomic and psychological integrity. In 1948, in a radical departure from previous definitions, the World Health Organization proposed a definition that aimed higher: linking health to well-being, in terms of "physical and social well-being, not the absence of disease and infirmity". Although this definition was welcomed by some as being innovative, it was criticized as being vague, excessively broad and was not construed as measurable. For a long time, it was set aside as an impractical ideal and most discussions of health returned to the practicality of the biomedical model.
Just as there was a shift from viewing disease as a state to thinking of it as a process, the same shift happened in definitions of health. Again, the WHO played a leading role when it fostered the development of the health promotion movement in the 1980s; this brought in a new conception of health, not as a state, but in dynamic terms of resiliency, in other words, as "a resource for living". 1984 WHO revised the definition of health defined it as "the extent to which an individual or group is able to realize aspirations and satisfy needs and to change or cope with the environment. Health is a resource for not the objective of living. Thus, health referred to the ability to recover from insults. Mental, intellectual and social health referred to a person's ability to handle stress, to acquire skills, to maintain relationships, all of which form resources for resiliency and independent living; this opens up many possibilities for health to be taught and learned. Since the late 1970s, the federal Healthy People Initiative has been a visible component of the United States’ approach to improving population health.
In each decade, a new version of Healthy People is issued, featuring updated goals and identifying topic areas and quantifiable objectives for health improvement during the succeeding ten years, with assessment at that point of progress or lack thereof. Progress has been limited to many objectives, leading to concerns about the effectiveness of Healthy People in shaping outcomes in the context of a decentralized and uncoordinated US health system. Healthy People 2020 gives more prominence to health promotion and preventive approaches and adds a substantive focus on the importance of addressing social determinants of health. A new expanded digital interface facilitates use and dissemination rather than bulky printed books as produced in the past; the impact of these changes to Healthy People will be determined in the coming years. Systematic activities to prevent or cure health problems and promote good health in humans are undertaken by health care providers. Applications with regard to animal health are covered by the veterinary sciences.
The term "healthy" is widely used in the context of many types of non-living organizations and their impacts for the benefit of humans, such as in the sense of healthy communities, healthy cities or healthy environments. In addition to health care interventions and a person's surroundings, a number of other factors are known to influence the health status of individuals, including their background and economic, social conditions and spirituality. Studies have shown. In the first decade of the 21st century, the conceptualization of health as an ability opened the door for self-assessments to become the main indicators to judge the performance of efforts aimed at improving human health, it created the opportunity for every person to feel healthy in the presence of multiple chronic diseases, or a terminal condition, for the re-examination of determinants of health, away from the traditional approach that focuses on the reduction of the prevalence of diseases. The context in which an individual lives is of great importance for both his health status and quality of their life It is recognized that health is maintained and improved not only through the advancement and application of health science, but through the efforts and intelligent lifestyle choices of the individual and society.
According to the World Health Organization, the main determinants of health include the social and economic environment, the physical environment and the person's individual characteristics and behaviors. More key factors that have been found to influence whether people are healthy or unhealthy include the following: An increasing number of studies and reports from different organizations and contexts examine the linkages between health and different factors, including lifestyles, health care organization and health policy, one specific health policy brought into many countries in recent years was the introduction of the sugar tax. Beve
According to many definitions, a disability is an impairment that may be cognitive, intellectual, physical, sensory, or some combination of these. Other definitions describe disability as the societal disadvantage arising from such impairments. Disability affects a person's life activities and may be present from birth or occur during a person's lifetime. Disabilities is an umbrella term, covering impairments, activity limitations, participation restrictions. An impairment is a problem in body structure. Disability is thus not just a health problem, it is a complex phenomenon, reflecting the interaction between features of a person’s body and features of the society in which he or she lives. Disability is a contested concept, with different meanings in different communities, it may be used to refer to physical or mental attributes that some institutions medicine, view as needing to be fixed. It may refer to limitations imposed on people by the constraints of an ableist society. Or the term may serve to refer to the identity of disabled people.
Physiological functional capacity is a related term that describes an individual's performance level. It gauges one's ability to perform the physical tasks of daily life and the ease with which these tasks are performed. PFC declines with advancing age to result in frailty, cognitive disorders or physical disorders, all of which may lead to labeling individuals as disabled; the discussion over disability's definition arose out of disability activism in the United States and the United Kingdom in the 1970s, which challenged how the medical concept of disability dominated perception and discourse about disabilities. Debates about proper terminology and their implied politics continue in disability communities and the academic field of disability studies. In some countries, the law requires that disabilities are documented by a healthcare provider in order to assess qualifications for disability benefits. For the purposes of the Americans with Disabilities Act of 1990, the Equal Employment Opportunity Commission regulations provide a list of conditions that should be concluded to be disabilities: deafness, blindness, an intellectual disability or missing limbs or mobility impairments requiring the use of a wheelchair, cancer, cerebral palsy, epilepsy, Human Immunodeficiency Virus infection, multiple sclerosis, muscular dystrophy, major depressive disorder, bipolar disorder, post-traumatic stress disorder, obsessive compulsive disorder, schizophrenia.
Contemporary understandings of disability derive from concepts that arose during the West's scientific Enlightenment. During the Middle Ages and other conditions were thought to be caused by demons, they were thought to be part of the natural order during and in the fallout of the Plague, which wrought impairments throughout the general population. In the early modern period there was a shift to seeking biological causes for physical and mental differences, as well as heightened interest in demarcating categories: for example, Ambroise Pare, in the sixteenth century, wrote of "monsters", "prodigies", "the maimed"; the European Enlightenment's emphases on knowledge derived from reason and on the value of natural science to human progress helped spawn the birth of institutions and associated knowledge systems that observed and categorized human beings. Contemporary concepts of disability are rooted in eighteenth- and nineteenth-century developments. Foremost among these was the development of clinical medical discourse, which made the human body visible as a thing to be manipulated and transformed.
These worked in tandem with scientific discourses that sought to classify and categorize and, in so doing, became methods of normalization. The concept of the "norm" developed in this time period, is signaled in the work of the Belgian statistician, sociologist and astronomer Adolphe Quetelet, who wrote in the 1830s of l'homme moyen – the average man. Quetelet postulated that one could take the sum of all people's attributes in a given population and find their average, that this figure should serve as a norm toward which all should aspire; this idea of a statistical norm threads through the rapid take up of statistics gathering by Britain, United States, the Western European states during this time period, it is tied to the rise of eugenics. Disability, as well as other concepts including: abnormal, non-normal, normalcy came from this; the circulation of these concepts is evident in the popularity of the freak show, where showmen profited from exhibiting people who deviated from those norms.
With the rise of eugenics in the latter part of the nineteenth century, such deviations were viewed as dangerous to the health of entire populations. With disability viewed as part of a person's biological make-up and thus their genetic inheritance, scientists turned their attention to notions of weeding such "deviations" out of the gene pool. Various metrics for assessing a person's genetic fitness, which were used to deport, sterilize, or institutionalize those deemed unfit. At the end of the Second World War, with the example of Nazi eugenics, eugenics faded from public discourse, d