Venoyl-CoA hydratase 2

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Enoyl-CoA hydratase 2
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Enoyl-CoA hydratase 2 (EC, 2-enoyl-CoA hydratase 2, AtECH2, ECH2, MaoC, MFE-2, PhaJAc, D-3-hydroxyacyl-CoA hydro-lyase, D-specific 2-trans-enoyl-CoA hydratase) is an enzyme with systematic name (3R)-3-hydroxyacyl-CoA hydro-lyase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

(3R)-3-hydroxyacyl-CoA (2E)-2-enoyl-CoA + H2O

This enzyme catalyses a hydration step in peroxisomal beta-oxidation.


  1. ^ Koski, K.M.; Haapalainen, A.M.; Hiltunen, J.K.; Glumoff, T. (2005). "Crystal structure of 2-enoyl-CoA hydratase 2 from human peroxisomal multifunctional enzyme type 2". J. Mol. Biol. 345: 1157–1169. doi:10.1016/j.jmb.2004.11.009. PMID 15644212. 
  2. ^ Fukui, T.; Shiomi, N.; Doi, Y. (1998). "Expression and characterization of (R)-specific enoyl coenzyme A hydratase involved in polyhydroxyalkanoate biosynthesis by Aeromonas caviae". J. Bacteriol. 180: 667–673. PMC 106937Freely accessible. PMID 9457873. 
  3. ^ Koski, M.K.; Haapalainen, A.M.; Hiltunen, J.K.; Glumoff, T. (2003). "Crystallization and preliminary crystallographic data of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis peroxisomal multifunctional enzyme type 2". Acta Crystallogr. D. 59: 1302–1305. doi:10.1107/s090744490300982x. PMID 12832794. 
  4. ^ Hisano, T.; Fukui, T.; Iwata, T.; Doi, Y. (2001). "Crystallization and preliminary X-ray analysis of (R)-specific enoyl-CoA hydratase from Aeromonas caviae involved in polyhydroxyalkanoate biosynthesis". Acta Crystallogr. D. 57: 145–147. doi:10.1107/s0907444900014062. PMID 11134939. 
  5. ^ Goepfert, S.; Hiltunen, J.K.; Poirier, Y. (2006). "Identification and functional characterization of a monofunctional peroxisomal enoyl-CoA hydratase 2 that participates in the degradation of even cis-unsaturated fatty acids in Arabidopsis thaliana". J. Biol. Chem. 281: 35894–35903. doi:10.1074/jbc.m606383200. PMID 16982622. 
  6. ^ Engeland, K.; Kindl, H. (1991). "Evidence for a peroxisomal fatty acid β-oxidation involving D-3-hydroxyacyl-CoAs. Characterization of two forms of hydro-lyase that convert D-(-)-3-hydroxyacyl-CoA into 2-trans-enoyl-CoA". Eur. J. Biochem. 200: 171–178. doi:10.1111/j.1432-1033.1991.tb21064.x. PMID 1879422. 

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