Virus is a 1999 American science fiction horror film directed by visual effects artist John Bruno and starring Jamie Lee Curtis, William Baldwin and Donald Sutherland. Based on the comic book of the same name by Chuck Pfarrer, it tells the story of a ship beset by a malevolent extraterrestrial entity that seeks to turn humanity into cyborg slaves.

Jamie Lee Curtis is an American actress, producer, and children's author. Known for her performances in the horror and slasher genres, she is regarded as a scream queen, in addition to roles in comedies. Curtis has received multiple accolades, including an Academy Award, a BAFTA Award, and two Golden Globe Awards, as well as nominations for an Emmy Award and a Grammy Award.