In cell biology, the nucleus is a membrane-bound organelle found in eukaryotic cells. Eukaryotes have a single nucleus, but a few cell types, such as mammalian red blood cells, have no nuclei, a few others including osteoclasts have many; the cell nucleus contains all of the cell's genome, except for a small fraction of mitochondrial DNA, organized as multiple long linear DNA molecules in a complex with a large variety of proteins, such as histones, to form chromosomes. The genes within these chromosomes are structured in such a way to promote cell function; the nucleus maintains the integrity of genes and controls the activities of the cell by regulating gene expression—the nucleus is, the control center of the cell. The main structures making up the nucleus are the nuclear envelope, a double membrane that encloses the entire organelle and isolates its contents from the cellular cytoplasm, the nuclear matrix, a network within the nucleus that adds mechanical support, much like the cytoskeleton, which supports the cell as a whole.
Because the nuclear envelope is impermeable to large molecules, nuclear pores are required to regulate nuclear transport of molecules across the envelope. The pores cross both nuclear membranes, providing a channel through which larger molecules must be transported by carrier proteins while allowing free movement of small molecules and ions. Movement of large molecules such as proteins and RNA through the pores is required for both gene expression and the maintenance of chromosomes. Although the interior of the nucleus does not contain any membrane-bound subcompartments, its contents are not uniform, a number of nuclear bodies exist, made up of unique proteins, RNA molecules, particular parts of the chromosomes; the best-known of these is the nucleolus, involved in the assembly of ribosomes. After being produced in the nucleolus, ribosomes are exported to the cytoplasm where they translate mRNA; the nucleus was the first organelle to be discovered. What is most the oldest preserved drawing dates back to the early microscopist Antonie van Leeuwenhoek.
He observed the nucleus, in the red blood cells of salmon. Unlike mammalian red blood cells, those of other vertebrates still contain nuclei; the nucleus was described by Franz Bauer in 1804 and in more detail in 1831 by Scottish botanist Robert Brown in a talk at the Linnean Society of London. Brown was studying orchids under the microscope when he observed an opaque area, which he called the "areola" or "nucleus", in the cells of the flower's outer layer, he did not suggest a potential function. In 1838, Matthias Schleiden proposed that the nucleus plays a role in generating cells, thus he introduced the name "cytoblast", he believed that he had observed new cells assembling around "cytoblasts". Franz Meyen was a strong opponent of this view, having described cells multiplying by division and believing that many cells would have no nuclei; the idea that cells can be generated de novo, by the "cytoblast" or otherwise, contradicted work by Robert Remak and Rudolf Virchow who decisively propagated the new paradigm that cells are generated by cells.
The function of the nucleus remained unclear. Between 1877 and 1878, Oscar Hertwig published several studies on the fertilization of sea urchin eggs, showing that the nucleus of the sperm enters the oocyte and fuses with its nucleus; this was the first time. This was in contradiction to Ernst Haeckel's theory that the complete phylogeny of a species would be repeated during embryonic development, including generation of the first nucleated cell from a "monerula", a structureless mass of primordial mucus. Therefore, the necessity of the sperm nucleus for fertilization was discussed for quite some time. However, Hertwig confirmed his observation in other animal groups, including amphibians and molluscs. Eduard Strasburger produced the same results for plants in 1884; this paved the way to assign the nucleus an important role in heredity. In 1873, August Weismann postulated the equivalence of the maternal and paternal germ cells for heredity; the function of the nucleus as carrier of genetic information became clear only after mitosis was discovered and the Mendelian rules were rediscovered at the beginning of the 20th century.
The nucleus is the largest organelle in animal cells. In mammalian cells, the average diameter of the nucleus is 6 micrometres, which occupies about 10% of the total cell volume; the contents of the nucleus are held in the nucleoplasm similar to the cytoplasm in the rest of the cell. The fluid component of this is termed the nucleosol, similar to the cytosol in the cytoplasm. In most types of granulocyte, a white blood cell, the nucleus is lobated and can be bi-lobed, tri-lobed or multi-lobed; the nuclear envelope, otherwise known as nuclear membrane, consists of two cellular membranes, an inner and an outer membrane, arranged parallel to one another and separated by 10 to 50 nanometres. The nuclear envelope encloses the nucleus and separates the cell's genetic material from the surrounding cytoplasm, serving as a barrier to prevent macromolecules from diffusing between the nucleoplasm and the cytoplasm; the outer nuclear membrane is continuous with the membrane of the rough endoplasmic reticulum, is studded with ribosomes.
The space between the membranes is called the perinuclear space and is continuous with the RER lumen. Nuclear pores, which provide aqueous cha
The cell is the basic structural and biological unit of all known living organisms. A cell is the smallest unit of life. Cells are called the "building blocks of life"; the study of cells is called cellular biology. Cells consist of cytoplasm enclosed within a membrane, which contains many biomolecules such as proteins and nucleic acids. Organisms can be classified as multicellular; the number of cells in plants and animals varies from species to species, it has been estimated that humans contain somewhere around 40 trillion cells. Most plant and animal cells are visible only under a microscope, with dimensions between 1 and 100 micrometres. Cells were discovered by Robert Hooke in 1665, who named them for their resemblance to cells inhabited by Christian monks in a monastery. Cell theory, first developed in 1839 by Matthias Jakob Schleiden and Theodor Schwann, states that all organisms are composed of one or more cells, that cells are the fundamental unit of structure and function in all living organisms, that all cells come from pre-existing cells.
Cells emerged on Earth at least 3.5 billion years ago. Cells are of two types: eukaryotic, which contain a nucleus, prokaryotic, which do not. Prokaryotes are single-celled organisms, while eukaryotes can be either single-celled or multicellular. Prokaryotes include two of the three domains of life. Prokaryotic cells were the first form of life on Earth, characterised by having vital biological processes including cell signaling, they are simpler and smaller than eukaryotic cells, lack membrane-bound organelles such as a nucleus. The DNA of a prokaryotic cell consists of a single chromosome, in direct contact with the cytoplasm; the nuclear region in the cytoplasm is called the nucleoid. Most prokaryotes are the smallest of all organisms ranging from 0.5 to 2.0 µm in diameter. A prokaryotic cell has three architectural regions: Enclosing the cell is the cell envelope – consisting of a plasma membrane covered by a cell wall which, for some bacteria, may be further covered by a third layer called a capsule.
Though most prokaryotes have both a cell membrane and a cell wall, there are exceptions such as Mycoplasma and Thermoplasma which only possess the cell membrane layer. The envelope gives rigidity to the cell and separates the interior of the cell from its environment, serving as a protective filter; the cell wall consists of peptidoglycan in bacteria, acts as an additional barrier against exterior forces. It prevents the cell from expanding and bursting from osmotic pressure due to a hypotonic environment; some eukaryotic cells have a cell wall. Inside the cell is the cytoplasmic region that contains the genome and various sorts of inclusions; the genetic material is found in the cytoplasm. Prokaryotes can carry extrachromosomal DNA elements called plasmids, which are circular. Linear bacterial plasmids have been identified in several species of spirochete bacteria, including members of the genus Borrelia notably Borrelia burgdorferi, which causes Lyme disease. Though not forming a nucleus, the DNA is condensed in a nucleoid.
Plasmids encode additional genes, such as antibiotic resistance genes. On the outside and pili project from the cell's surface; these are structures made of proteins that facilitate communication between cells. Plants, fungi, slime moulds and algae are all eukaryotic; these cells are about fifteen times wider than a typical prokaryote and can be as much as a thousand times greater in volume. The main distinguishing feature of eukaryotes as compared to prokaryotes is compartmentalization: the presence of membrane-bound organelles in which specific activities take place. Most important among these is a cell nucleus, an organelle that houses the cell's DNA; this nucleus gives the eukaryote its name, which means "true kernel". Other differences include: The plasma membrane resembles that of prokaryotes in function, with minor differences in the setup. Cell walls may not be present; the eukaryotic DNA is organized in one or more linear molecules, called chromosomes, which are associated with histone proteins.
All chromosomal DNA is stored in the cell nucleus, separated from the cytoplasm by a membrane. Some eukaryotic organelles such as mitochondria contain some DNA. Many eukaryotic cells are ciliated with primary cilia. Primary cilia play important roles in chemosensation and thermosensation. Cilia may thus be "viewed as a sensory cellular antennae that coordinates a large number of cellular signaling pathways, sometimes coupling the signaling to ciliary motility or alternatively to cell division and differentiation." Motile eukaryotes can move using motile flagella. Motile cells are absent in flowering plants. Eukaryotic flagella are more complex than those of prokaryotes. All cells, whether prokaryotic or eukaryotic, have a membrane that envelops the cell, regulates what moves in and out, maintains the electric potential of the cell. Inside the membrane, the cytoplasm takes up most of the cell's volume. All cells possess DNA, the hereditary material of genes, RNA, containing the information necessary to build various proteins such as enzymes, the cell's primary machinery.
There are other kinds of biomolecules in cells. This article lists these primary cellular components briefly
Pyknosis, or karyopyknosis, is the irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis. It is followed by fragmentation of the nucleus. Pyknosis is observed in the maturation of erythrocytes and the neutrophil; the maturing metarubricyte will condense its nucleus before expelling it to become a reticulocyte. The maturing neutrophil will condense its nucleus into several connected lobes that stay in the cell until the end of its cell life. Pyknotic nuclei are found in the zona reticularis of the adrenal gland, they are found in the keratinocytes of the outermost layer in parakeratinised epithelium. Apoptosis Karyolysis
Tobacco smoking is the practice of smoking tobacco and inhaling tobacco smoke. The practice is believed to have begun as early as 5000 -- 3000 BC in South America. Tobacco was introduced to Eurasia in the late 17th century by European colonists, where it followed common trade routes; the practice encountered criticism from its first import into the Western world onwards but embedded itself in certain strata of a number of societies before becoming widespread upon the introduction of automated cigarette-rolling apparatus. German scientists identified a link between smoking and lung cancer in the late 1920s, leading to the first anti-smoking campaign in modern history, albeit one truncated by the collapse of Nazi Germany at the end of World War II. In 1950, British researchers demonstrated a clear relationship between cancer. Evidence continued to mount in the 1980s. Rates of consumption declined. However, they continue to climb in the developing world. Smoking is the most common method of consuming tobacco, tobacco is the most common substance smoked.
The agricultural product is mixed with additives and combusted. The resulting smoke is inhaled and the active substances absorbed through the alveoli in the lungs or the oral mucosa. Combustion was traditionally enhanced by addition of potassium or nitrates. Many substances in cigarette smoke trigger chemical reactions in nerve endings, which heighten heart rate and reaction time, among other things. Dopamine and endorphins are released, which are associated with pleasure; as of 2008 to 2010, tobacco is used by about 49% of men and 11% of women aged 15 or older in fourteen low-income and middle-income countries, with about 80% of this usage in the form of smoking. The gender gap tends to be less pronounced in lower age groups. Many smokers begin during early adulthood. During the early stages, a combination of perceived pleasure acting as positive reinforcement and desire to respond to social peer pressure may offset the unpleasant symptoms of initial use, which include nausea and coughing. After an individual has smoked for some years, the avoidance of withdrawal symptoms and negative reinforcement become the key motivations to continue.
A study of first smoking experiences of seventh-grade students found out that the most common factor leading students to smoke is cigarette advertisements. Smoking by parents and friends encourages students to smoke. Smoking's history dates back to as early as 5000–3000 BC, when the agricultural product began to be cultivated in Mesoamerica and South America; the practice worked its way into shamanistic rituals. Many ancient civilizations – such as the Babylonians, the Indians, the Chinese – burnt incense during religious rituals. Smoking in the Americas had its origins in the incense-burning ceremonies of shamans but was adopted for pleasure or as a social tool; the smoking of tobacco and various hallucinogenic drugs was used to achieve trances and to come into contact with the spirit world. To stimulate respiration, tobacco smoke enemas were used. Eastern North American tribes would carry large amounts of tobacco in pouches as a accepted trade item and would smoke it in ceremonial pipes, either in sacred ceremonies or to seal bargains.
Adults as well as children enjoyed the practice. It was believed that tobacco was a gift from the Creator and that the exhaled tobacco smoke was capable of carrying one's thoughts and prayers to heaven. Apart from smoking, tobacco had a number of uses as medicine; as a pain killer it was used for earache and toothache and as a poultice. Smoking was said by the desert Indians to be a cure for colds if the tobacco was mixed with the leaves of the small Desert sage, Salvia dorrii, or the root of Indian balsam or cough root, Leptotaenia multifida, the addition of, thought to be good for asthma and tuberculosis. In 1612, six years after the settlement of Jamestown, John Rolfe was credited as the first settler to raise tobacco as a cash crop; the demand grew as tobacco, referred to as "brown gold", revived the Virginia joint stock company from its failed gold expeditions. In order to meet demands from the Old World, tobacco was grown in succession depleting the soil; this became a motivator to settle west into the unknown continent, an expansion of tobacco production.
Indentured servitude became the primary labor force up until Bacon's Rebellion, from which the focus turned to slavery. This trend abated following the American Revolution as slavery became regarded as unprofitable. However, the practice was revived in 1794 with the invention of the cotton gin. Frenchman Jean Nicot introduced tobacco to France in 1560, tobacco spread to England; the first report of a smoking Englishman is of a sailor in Bristol in 1556, seen "emitting smoke from his nostrils". Like tea and opium, tobacco was just one of many intoxicants, used as a form of medicine. Tobacco was introduced around 1600 by French merchants in what today is modern-day Gambia and Senegal. At the same time, caravans from Morocco brought tobacco to the
Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. Epithelial tissues line the outer surfaces of organs and blood vessels throughout the body, as well as the inner surfaces of cavities in many internal organs. An example is the outermost layer of the skin. There are three principal shapes of epithelial cell: squamous and cuboidal; these can be arranged in a single layer of cells as simple epithelium, either squamous, columnar, or cuboidal, or in layers of two or more cells deep as stratified, either squamous, columnar or cuboidal. In some tissues, a layer of columnar cells may appear to be stratified due to the placement of the nuclei; this sort of tissue is called pseudostratified. All glands are made up of epithelial cells. Functions of epithelial cells include secretion, selective absorption, transcellular transport, sensing. Epithelial layers contain no blood vessels, so they must receive nourishment via diffusion of substances from the underlying connective tissue, through the basement membrane.
Cell junctions are well employed in epithelial tissues. In general, epithelial tissues are classified by the number of their layers and by the shape and function of the cells; the three principal shapes associated with epithelial cells are—squamous and columnar. Squamous epithelium has cells; this is found as the lining of the mouth, the blood vessels and in the alveoli of the lungs. Cuboidal epithelium has cells whose height and width are the same. Columnar epithelium has cells taller. By layer, epithelium is classed as either simple epithelium, only one cell thick or stratified epithelium having two or more cells in thickness or multi-layered – as stratified squamous epithelium, stratified cuboidal epithelium, stratified columnar epithelium, both types of layering can be made up of any of the cell shapes. However, when taller simple columnar epithelial cells are viewed in cross section showing several nuclei appearing at different heights, they can be confused with stratified epithelia; this kind of epithelium is therefore described as pseudostratified columnar epithelium.
Transitional epithelium has cells that can change from squamous to cuboidal, depending on the amount of tension on the epithelium. Simple epithelium is a single layer of cells with every cell in direct contact with the basement membrane that separates it from the underlying connective tissue. In general, it is found where filtration occur; the thinness of the epithelial barrier facilitates these processes. In general, simple epithelial tissues are classified by the shape of their cells; the four major classes of simple epithelium are: simple squamous. Simple squamous. Simple cuboidal: these cells may have secretory, absorptive, or excretory functions. Examples include small collecting ducts of kidney and salivary gland. Simple columnar. Non-ciliated epithelium can possess microvilli; some tissues are referred to as simple glandular columnar epithelium. These secrete mucus and are found in stomach and rectum. Pseudostratified columnar epithelium; the ciliated type is called respiratory epithelium as it is exclusively confined to the larger respiratory airways of the nasal cavity and bronchi.
Stratified epithelium differs from simple epithelium. It is therefore found where body linings have to withstand mechanical or chemical insult such that layers can be abraded and lost without exposing subepithelial layers. Cells flatten as the layers become more apical, though in their most basal layers the cells can be squamous, cuboidal or columnar. Stratified epithelia can have the following specializations: The basic cell types are squamous and columnar classed by their shape. Cells of epithelial tissue are scutoid shaped packed and form a continuous sheet, they have no intercellular spaces. All epithelia is separated from underlying tissues by an extracellular fibrous basement membrane; the lining of the mouth, lung alveoli and kidney tubules are all made of epithelial tissue. The lining of the blood and lymphatic vessels are of a specialised form of epithelium called endothelium. Epithelium lines both the outside and the inside cavities and lumina of bodies; the outermost layer of human skin is composed of dead stratified squamous, keratinized epithelial cells.
Tissues that line the inside of the mouth, the esophagus, the vagina, part of the rectum are composed of nonkeratinized stratified squamous epithelium. Other surfaces that separate body cavities from the outside environment are lined by simple squamous, columnar, or pseudostratified epithelial cells. Other epithelial cells line the insides of the lungs, the gastrointestinal tract, the reproductive and urinary tracts, make up the exocrine and endocrine glands; the outer surface of the cornea is covered with fast-growing regenerated epithelial cells. A specialised form of epithelium – endothelium forms the inner lining of blood vessels and the heart, is known as vascular endotheliu
The mandible, lower jaw or jawbone is the largest and lowest bone in the human face. It holds the lower teeth in place; the mandible sits beneath the maxilla. It is the only movable bone of the skull; the bone is formed in the fetus from a fusion of the left and right mandibular prominences, the point where these sides join, the mandibular symphysis, is still visible as a faint ridge in the midline. Like other symphyses in the body, this is a midline articulation where the bones are joined by fibrocartilage, but this articulation fuses together in early childhood; the word "mandible" derives from the Latin word mandibula, "jawbone", from mandere "to chew" and -bula. The mandible consists of: The body, found at the front A ramus on the left and the right, the rami rise up from the body of the mandible and meet with the body at the angle of the mandible or the gonial angle; the body of the mandible is curved, the front part gives structure to the chin. It has two borders. From the outside, the mandible is marked in the midline by a faint ridge, indicating the mandibular symphysis, the line of junction of the two pieces of which the bone is composed at an early period of life.
This ridge divides below and encloses a triangular eminence, the mental protuberance, the base of, depressed in the center but raised on either side to form the mental tubercle. On either side of the symphysis, just below the incisor teeth, is a depression, the incisive fossa, which gives origin to the mentalis and a small portion of the orbicularis oris. Below the second premolar tooth, on either side, midway between the upper and lower borders of the body, is the mental foramen, for the passage of the mental vessels and nerve. Running backward and upward from each mental tubercle is a faint ridge, the oblique line, continuous with the anterior border of the ramus. From the inside, the mandible appears concave. Near the lower part of the symphysis is a pair of laterally placed spines, termed the mental spines, which give origin to the genioglossus. Below these is a second pair of spines, or more a median ridge or impression, for the origin of the geniohyoid. In some cases, the mental spines are fused to form a single eminence, in others they are absent and their position is indicated by an irregularity of the surface.
Above the mental spines, a median foramen and furrow are sometimes seen. Below the mental spines, on either side of the middle line, is an oval depression for the attachment of the anterior belly of the digastric. Extending upward and backward on either side from the lower part of the symphysis is the mylohyoid line, which gives origin to the mylohyoid muscle. Above the anterior part of this line is a smooth triangular area against which the sublingual gland rests, below the hinder part, an oval fossa for the submandibular gland. Borders The superior or alveolar border, wider behind than in front, is hollowed into cavities, for the reception of the teeth. To the outer lip of the superior border, on either side, the buccinator is attached as far forward as the first molar tooth; the inferior border is rounded, longer than the superior, thicker in front than behind. The ramus of the human mandible has four sides, two surfaces, four borders, two processes. On the outside, the ramus marked by oblique ridges at its lower part.
On the inside at the center there is an oblique mandibular foramen, for the entrance of the inferior alveolar vessels and nerve. The margin of this opening is irregular. Behind this groove is a rough surface, for the insertion of the medial pterygoid muscle; the mandibular canal runs obliquely downward and forward in the ramus, horizontally forward in the body, where it is placed under the alveoli and communicates with them by small openings. On arriving at the incisor teeth, it turns back to communicate with the mental foramen, giving off two small canals which run to the cavities containing the incisor teeth. In the posterior two-thirds of the bone the canal is situated nearer the internal surface of the mandible, it contains the inferior alveolar vessels and nerve, from which branches are distributed to the teeth. Borders The lower border of the ramus is thick and continuous with the inferior border of the body of the bone. At its junction with the posterior border is the angle of the mandible, which may be either inverted or everted and is marked by rough, oblique ridges on each side, for the attachment of the masseter laterally, the medial pterygoid muscle medially.
The anterior border is thin above, thicker below, continuous with the oblique l
A gland is a group of cells in an animal's body that synthesizes substances for release into the bloodstream or into cavities inside the body or its outer surface. Every gland is formed by an ingrowth from an epithelial surface; this ingrowth may in the beginning possess a tubular structure, but in other instances glands may start as a solid column of cells which subsequently becomes tubulated. As growth proceeds, the column of cells may split or give off offshoots, in which case a compound gland is formed. In many glands, the number of branches is limited, in others a large structure is formed by repeated growth and sub-division; as a rule, the branches do not unite with one another, but in one instance, the liver, this does occur when a reticulated compound gland is produced. In compound glands the more typical or secretory epithelium is found forming the terminal portion of each branch, the uniting portions form ducts and are lined with a less modified type of epithelial cell. Glands are classified according to their shape.
If the gland retains its shape as a tube throughout it is termed a tubular gland. In the second main variety of gland the secretory portion is enlarged and the lumen variously increased in size; these are termed saccular glands. Glands are divided based on their function into two groups: Endocrine glands secrete substances that circulate through the blood stream; the glands secrete their products through basal lamina into the blood stream. Basil lamina can be seen as a layer around the glands to which a million, maybe more, tiny blood vessels are attached; these glands secrete hormones which play an important role in maintaining homeostasis. The pineal gland, thymus gland, pituitary gland, thyroid gland, the two adrenal glands are all endocrine glands. Exocrine glands secrete their products through a duct onto an outer or inner surface of the body, such as the skin or the gastrointestinal tract. Secretion is directly onto the apical surface; the glands in this group can be divided into three groups: Apocrine glands - a portion of the secreting cell's body is lost during secretion.'Apocrine glands' is used to refer to the apocrine sweat glands, however it is thought that apocrine sweat glands may not be true apocrine glands as they may not use the apocrine method of secretion, e.g. mammary gland, sweat gland of arm pit, pubic region, skin around anus and nipples.
Holocrine glands - the entire cell disintegrates to secrete its substances, e.g. sebaceous glands: meibomian and zeis glands. Merocrine glands - cells secrete their substances by exocytosis, e.g. mucous and serous glands. The type of secretory product of exocrine glands may be one of three categories: Serous glands secrete a watery protein-rich, fluid-like product, e.g. sweat glands. Mucous glands secrete a viscous product, rich in carbohydrates, e.g. goblet cells. Sebaceous glands secrete a lipid product; these glands are known as oil glands, e.g. Fordyce spots and meibomian glands. Adenosis is any disease of a gland; the diseased gland has abnormal formation or development of glandular tissue, sometimes tumorous