Wayne County is the most populous county in the U.S. state of Michigan. As of 2020, the United States Census placed its population at 1,793,561, making it the 19th-most populous county in the United States. The county seat is Detroit. The county was founded in 1796 and organized in 1815. Wayne County is included in the Detroit-Warren-Dearborn, MI Metropolitan Statistical Area. It is one of several U.S. counties named after Revolutionary War-era general Anthony Wayne.

Detroit is the most populous city in the U.S. state of Michigan. It is the largest U.S. city on the United States–Canada border, and the seat of government of Wayne County. Detroit had a population of 639,111 at the 2020 census, making it the 29th-most populous city in the United States. The Metro Detroit area, home to 4.3 million people, is the second-largest in the Midwest after the Chicago metropolitan area and the 14th-largest in the United States. A significant cultural center, Detroit is known for its contributions to music, art, architecture and design, in addition to its historical automotive background.