William Wilkins was an American judge and politician from Pennsylvania who served as a Jacksonian member of the United States Senate from 1831 to 1834 and as a Democratic member of the United States House of Representatives for Pennsylvania's 21st congressional district from 1843 to 1844. He served as a member of both houses of the Pennsylvania General Assembly, a United States district judge of the United States District Court for the Western District of Pennsylvania, United States Minister to Russia and the 19th United States Secretary of War.

Pennsylvania's twenty-first congressional district was a congressional district in northwestern Pennsylvania. It was created following the 1830 census and was disbanded after the 2000 census removed two representatives from Pennsylvania.