Wilson's disease is a genetic disorder in which excess copper builds up in the body. Symptoms are related to the brain and liver. Liver-related symptoms include vomiting, fluid build up in the abdomen, swelling of the legs, yellowish skin and itchiness. Brain-related symptoms include tremors, muscle stiffness, trouble speaking, personality changes and seeing or hearing things that others do not. Wilson's disease is caused by a mutation in the Wilson disease protein gene; this protein transports excess copper into bile. The condition is autosomal recessive. Diagnosis may be difficult and involves a combination of blood tests, urine tests and a liver biopsy. Genetic testing may be used to screen family members of those affected. Wilson's disease is treated with dietary changes and medication. Dietary changes involve eating a low-copper diet and not using copper cookware. Medications used include chelating agents such as trientine and d-penicillamine and zinc supplements. Complications of Wilson's disease can include liver liver cancer and kidney problems.
A liver transplant may be helpful in those in whom other treatments are not effective or if liver failure occurs. Wilson's disease occurs in about 1 in 30,000 people. Symptoms begin between the ages of 5 and 35 years, it was first described in 1854 by German pathologist Friedrich Theodor von Frerichs and is named after British neurologist Samuel Wilson. The main sites of copper accumulation are the liver and the brain, liver disease and neuropsychiatric symptoms are the main features that lead to diagnosis. People with liver problems tend to come to medical attention earlier as children or teenagers, than those with neurological and psychiatric symptoms, who tend to be in their twenties or older; some are identified. Liver disease may present itself as tiredness, increased bleeding tendency or confusion and portal hypertension; the latter, a condition in which the pressure in the portal vein is markedly increased, leads to esophageal varices, blood vessels in the esophagus that may bleed in a life-threatening fashion, as well as enlargement of the spleen and accumulation of fluid in the abdominal cavity.
On examination, signs of chronic liver disease such as spider angiomata may be observed. Chronic active hepatitis has caused cirrhosis of the liver in most by the time they develop symptoms. While most people with cirrhosis have an increased risk of hepatocellular carcinoma, this risk is very low in Wilson's disease. About 5% of all people are diagnosed only when they develop fulminant acute liver failure in the context of a hemolytic anemia; this leads to abnormalities in protein metabolism by the liver. The deranged protein metabolism leads to the accumulation of waste products such as ammonia in the bloodstream; when these irritate the brain, the person develops hepatic encephalopathy. About half the people with Wilson's disease have psychiatric symptoms. Most have mild cognitive deterioration and clumsiness, as well as changes in behavior. Specific neurological symptoms then follow in the form of parkinsonism with or without a typical hand tremor, masked facial expressions, slurred speech, ataxia or dystonia.
Seizures and migraine appear to be more common in Wilson's disease. A characteristic tremor described as "wing-beating tremor" is encountered in many people with Wilson's. Cognition can be affected in Wilson's disease; this comes in two, not mutually exclusive, categories: frontal lobe disorder and subcortical dementia. It is suggested that these cognitive involvements are related and linked to psychiatric manifestations of the disease. Psychiatric problems due to Wilson's disease may include behavioral changes, anxiety disorders, psychosis. Psychiatric symptoms are seen in conjunction with neurological symptoms and are manifested on their own; these symptoms are poorly defined and can sometimes be attributed to other causes. Because of this, diagnosis of Wilson's disease is made when only psychiatric symptoms are present. Medical conditions have been linked with copper accumulation in Wilson's disease: Eyes: Kayser–Fleischer rings, a pathognomonic sign, may be visible in the cornea of the eyes, either directly or on slit lamp examination as deposits of copper in a ring around the cornea.
They are due to copper deposition in Descemet's membrane. They do not occur in all people with Wilson's disease. Wilson's disease is associated with sunflower cataracts exhibited by brown or green pigmentation of the anterior and posterior lens capsule. Neither
Victor Andrade Santos is a Brazilian professional footballer who plays for Portuguese club G. D. Estoril Praia. Born in Carmópolis, Victor Andrade joined Vitória's youth setup in 2005, aged 10. A year he moved to Benfica in a trial basis, remaining in the club for a couple of months and appearing in youth tournaments with the Lisbon club. Due to his age, however, he returned to Brazil and signed for Santos in 2007. In October 2011 he signed a three-year deal with a buyout clause set at € 50 million. Touted as a next Neymar by the media, he made his professional – and Série A – debut for Santos on 6 June 2012, aged only 16, replacing Alan Kardec in a 1–1 home draw against Fluminense, he went on to score 3 goals in 19 matches in his first season, most notably in a 2–0 home success against Cruzeiro where scored the first and assist another, receiving praise from Muricy Ramalho and Neymar for his performance. Andrade appeared in the following campaigns, opted not to renew his contract with Santos.
On 11 July 2014, he returned to Benfica, the incumbent title holders, penning a six-year contract and being assigned to the reserves in Segunda Liga. He made his debut on 17 September 2014, replacing Gonçalo Guedes on the 87th minute in a 2–2 home draw with Atlético CP, he scored his first goal on 5 October 2014, netting his side's second in a 2–2 away draw against Feirense, ended the season with 32 appearances and four goals, including one to Porto B on 17 May 2015. In 2015–16, Andrade remained assigned to Benfica B, he made his debut for the first team against them and assisted Jonas for the 3–0 and took part in the fourth goal, scored by Nélson Semedo. He played again against Arouca, Moreirense, but was soon dropped again to the reserve team, as Rui Vitória favoured Gonçalo Guedes for his position. On 31 October, Benfica disclosed on their annual financial report, that Andrade had cost €3.94 million on agent fees. On 1 February 2016, he joined Vitória de Guimarães on loan until the end of the season.
Five days he made his debut with Guimarães, on 20 March, started his first game for them. In April, he was assigned to Vitória Guimarães B. In June 2016, Andrade went on his second loan spell, joining German club 1860 Munich on a season-long deal. On 27 October, he sustained a cruciate ligament rupture to his left knee and was sidelined for six months, he was only fit to play again in May 2017. On 29 August 2017, Andrade moved to Estoril. A year he returned to Brazil to play for Chapecoense, on a one-year loan deal; as of 3 January 2020 SantosRecopa Sudamericana: 2012BenficaPrimeira Liga: 2015–16 Brazil U208 Nations International Tournament: 2012 Victor Andrade at ForaDeJogo
Una familia de diez known as Una familia de diez + 2 for the second season, is a Mexican television sitcom that centers on the López household, a middle class Mexican family that endures hilarious situations. They live in an apartment which holds living space for them, it premiered on Las Estrellas on March 22, 2007. Plácido López is a middle-class accountant, tiring of being the sole provider for his family, his wife Renata and his 2 children and Martina, they live happy in a small apartment in the Colonia Doctores in Mexico City. Five years ago, Aunt Licha and her daughter have arrived since both were abandoned by her husband, after he "uncovered" as homosexual. A year ago, Don Arnoldo López, Plácido's father, moved to live with them since he has nowhere else to go. Subsequently, an indigenous named Tecla is integrated, who comes from the same town where Don Arnoldo lived and by accident makes constant references about Don Arnoldo having a secret relationship with her mother. Placido works in a company that belongs to Don Justo Del Valle, who has a daughter named Gabriela del Valle from whom Plutarco falls and in love.
Plutarco and Gaby marry secretly, after they learn that they will become parents, why Gaby moves in with the López family. A few chapters Aldolfo, La Nena's boyfriend arrives and moves in, after finding out that La Nena is pregnant. Thus, in a short time, the tranquility of the López home becomes an agglomeration of ten people in the small apartment. There is endless fun and funny problems derived from the lack of space, economic problems and the ingenuity and humor of each of the characters as well as some other sporadic characters that give a special touch to this series. In the final episode of the series, due to good luck, in a television contest, the López win a house. In season two, after the house they won more than ten years ago burns down, they are now forced to return to the apartment where they lived before. But, now with two new members, the children of Plutarco & Gaby, La Nena & Aldolfo, the López family will live new troubles and problems, which will be solve with the support of the whole family.
Jorge Ortiz de Pinedo as Plácido López, is the patriarch of the family, Renata's husband and Martina's father. He was abandoned by his own father at the age of five. Placido works as an accountant for Don Justo del Valle, he is a pessimistic father, due to the laziness of his family; every time Placido complains, he reflects the spectacle and political situations that he are experienced at that time period. Eduardo Manzano as Don Arnoldo López, Plácido's father and Martina's grandfather, he hates work. He abandoned Placido during his fifth birthday, returned after some 40 years to live with his son and his family, he recommended Plácido to work for food. Tecla always brings up that Don Arnoldo had a secret relationship with her mother in their rural town of "Apaseo el Grande", he claims to have worked in many motion pictures of the Golden Age of Mexican Cinema, in seasons and well known American movies from the 90s and early 2000s while claiming to know many important Mexican and American actors, but he only knows actress Silvia Pinal.
Zully Keith as Renata González de López, Plácido's wife and Martina's mother. She is an optimistic housewife, who confuses her past love interests and affairs with her husband Plácido during her youth, she always tries to be happy, but is very distracted and sometimes says what she thinks. Andrea Torre as La Nena, Licha's daughter, Plácido and Renata's niece and Martina's cousin, Adolfo's wife and Victoria's mother, she is a hard worker and intelligent young woman. She is the pride of her uncle Plácido, she is a fiery and lustful women as far as love is concerned. Mariana Botas as Martina López and Renata's fresa daughter and Plutarco's sister, she is a young tantrum, arrogant women, who thinks is wealthy/fashionable and complains that her family not being rich and important like the families of her school friends. She does not get along with her cousin La Nena, but has a good relationship with her grandfather Don Arnoldo. Jessica Segura as Tecla, Don Arnoldo's goddaughter, from Apaseo el Grande.
She is the housekeeper of the López, she was recommended by her godfather to cook and clean in the house. She sometimes mentions her godfather's secret relatioship with her mother, she wants to become an actress and is picked on mainly by Plutarco and Martina. She is nicknamed "The Salma Hayek of Apaseo el Grande", "The daughter of Dolores del Río", "India María", "Daughter of Frida Kahlo". In the Season 2 finale, she leaves the López home to become an actress. Moisés Iván Mora as Aldolfo, La Nena's husband and Victoria's father, he was birth name is Aldolfo Mao Emiliano Lenin Fidel Castro Cienfuegos in the Estadio Azteca in 1977 during a Pumas soccer game. He is a young man who does not work, due to his political ideologies, since he is against capitalism and supports communism, he dresses up hippie like, always smells bad. He is a fan of Che Guevara. Daniela Luján as Gaby del Valle de López, Plutarco's wife, the daughter of Placido's employer and Justito's mother, she is a beautiful, elega