Y-chromosomal Aaron

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Y-chromosomal Aaron is the name given to the hypothesized most recent common ancestor of the majority of the patrilineal Jewish priestly caste known as Kohanim (singular "Kohen", also spelled "Cohen"). According to the Hebrew Bible, this ancestor was Aaron, the brother of Moses.

The original scientific research was based on the hypothesis that a majority of present-day Jewish Kohanim share a pattern of values for six Y-STR markers, which researchers named the Cohen Modal Haplotype (CMH).[1]

Subsequent research using twelve Y-STR markers indicated that about half of contemporary Jewish Kohanim shared Y-chromosomal J1 M267, (specifically haplogroup J-P58, also called J1c3), while other Kohanim share a different ancestry, including haplogroup J2a (J-M410).

Molecular phylogenetics research published in 2013 and 2016 for haplogroup J-M267 places the Y-chromosomal Aaron within subhaplogroup Z18271, age estimate 2638-3280 years Before Present (yBP).[2][3]

Background[edit]

For human beings, the normal number of chromosomes is 46, of which 23 are inherited from each parent. Two chromosomes, the X and Y, determine sex. Women have two X chromosomes, one inherited from each of their parents. Men have an X chromosome inherited from their mother, and a Y chromosome inherited from their father.

Males who share a common patrilineal ancestor also share a common Y chromosome, diverging only with respect to accumulated mutations, since Y-chromosomes are passed from father to son, all Kohanim men should theoretically have nearly identical Y chromosomes; this can be assessed with a genealogical DNA test. As the rate that mutations accumulate on the Y chromosome is relatively constant,[citation needed] scientists can estimate the elapsed time since two men had a common ancestor. (See molecular clock.)

Although Jewish identity has, since at least the second century CE, been passed by matrilineal descent according to Orthodox tradition (see: Who is a Jew?), membership in the group that comprises the Jewish priesthood (Kehuna), has been determined by patrilineal descent (see Presumption of priestly descent). Modern Kohanim are regarded in Judaism as male descendants of biblical Aaron, a direct patrilineal descendant of Abraham, according to the lineage recorded in the Tanakh (שמות / Sh'mot/Exodus 6).

Initial study[edit]

The Kohen hypothesis was first tested through DNA analysis in 1997 by Prof. Karl Skorecki and collaborators from Haifa, Israel. In their study, "Y chromosomes of Jewish priests," published in the journal Nature,[4] they found that the Kohanim appeared to share a different probability distribution compared to the rest of the Jewish population for the two Y-chromosome markers they tested (YAP and DYS19). They also found that the probabilities appeared to be shared by both Sephardic and Ashkenazi Kohens, pointing to a common Kohen population origin before the Jewish diaspora at the Destruction of the Second Temple. However, this study also indicated that only 48% of Ashkenazi Kohens and 58% of Sephardic Kohens have the J1 Cohen Modal Haplotype.

In a subsequent study the next year (Thomas MG et al., 1998),[1] the team increased the number of Y-STR markers tested to six, as well as testing more SNP markers. Again, they found that a clear difference was observable between the Kohanim population and the general Jewish population, with many of the Kohen STR results clustered around a single pattern they named the Kohen Modal Haplotype:

  xDE[4] xDE,PR[1] Hg J[5] CMH.1[1] CMH[1] CMH.1/HgJ CMH/HgJ
Ashkenazi Cohanim (AC): 98.5% 96% 87% 69% 45% 79% 52%
Sephardic Cohanim (SC): 100% 88% 75% 61% 56% 81% 75%
Ashkenazi Jews (AI): 82% 62% 37% 15% 13% 40% 35%
Sephardic Jews (SI): 85% 63% 37% 14% 10% 38% 27%

Here, becoming increasingly specific, xDE is the proportion who were not in Haplogroups D or E (from the original paper); xDE,PR is the proportion who were not in haplogroups D, E, P, Q or R; Hg J is the proportion who were in Haplogroup J (from the slightly larger panel studied by Behar et al. (2003)[5]); CMH.1 means "within one marker of the CMH-6"; and CMH is the proportion with a 6/6 match. The final two columns show the conditional proportions for CMH.1 and CMH, given membership of Haplogroup J.

The data show that the Kohanim were more than twice as likely to belong to Haplogroup J than the average non-Cohen Jew. Of those who did belong to Haplogroup J, the Kohanim were more than twice as likely to have an STR pattern close to the CMH-6, suggesting a much more recent common ancestry for most of them compared to an average non-Kohen Jew of Haplogroup J.

Dating[edit]

Thomas, et al. dated the origin of the shared DNA to approximately 3,000 years ago (with variance arising from different generation lengths). The techniques used to find Y-chromosomal Aaron were first popularized in relation to the search for the patrilineal ancestor of all contemporary living humans, Y-chromosomal Adam.

Molecular phylogenetic research published in 2013 and 2016 for haplogroup J-M267 places the Y-chromosomal Aaron within subhaplogroup Z18271, age estimate 2638-3280 years Before Present (yBP).[2][3]


Responses[edit]

The finding led to excitement in religious circles, with some seeing it as providing some proof of the historical veracity of the Priestly covenant[6] or other religious convictions.[7]

Following the discovery of the very high prevalence of 6/6 CMH matches amongst Kohanim, other researchers and analysts were quick to look for it, some groups have taken the presence of this haplotype as indicating possible Jewish ancestry, although the chromosome is not exclusive to Jews. It is widely found among other Semitic peoples of the Middle east.

Some persons said that the 6/6 matches found among male Lemba of Southern Africa confirmed their oral history of descent from Jews and connection to Jewish culture.(Thomas MG et al. 2000);[8] Dissenting interpretations however have been advanced in some recent research.[9][10][11]

Some researchers[who?] suggested that 4/4 matches found in non-Jewish Italians might be a genetic inheritance from Jewish slaves. They were deported from Judea by Emperor Titus in large numbers after the fall of the Temple in AD 70. Some men were put to work building the Colosseum in Rome, they were the start of a substantial Jewish community in Rome that developed in the early centuries of the Common Era.[citation needed]

Critics such as Avshalom Zoosmann-Diskin suggested that the paper's evidence was being overstated in terms of showing Jewish descent among these distant populations.[12]

Limitations[edit]

Principal components analysis scatterplot of Y-STR haplotypes from Haplogroup J, calculated using 6 STRs. With only six Y-STRs, it is not possible to resolve the different subgroups of Hg J.
Principal components analysis scatterplot of Y-STR haplotypes from Haplogroup J, calculated using 37 STRs. With 37 Y-STR markers, clearly distinct STR clusters can be resolved, matching the distinct J1, J2 and J2b subgroups, the haplotypes often associated with Cohen lineages in each group are highlighted as J1 C37 and J2 C37, respectively.

One source of early confusion was the low resolution and general coverage of the Cohen Modal Haplotype, the Cohen Modal Haplotype (CMH), while frequent amongst Kohanim, also appeared in the general populations of haplogroups J1 and J2 with no particular link to the Kohen ancestry. These haplogroups occur widely throughout the Middle East and beyond.[13][14] Thus, while many Kohanim have haplotypes close to the CMH, a greater number of such haplotypes worldwide belong to people with no apparent connection to the Jewish priesthood.

Individuals with at least 5/6 matches for the original 6-marker Cohen Modal Haplotype are found across the Middle East, with significant frequencies among various Arab populations, mainly those with the J1 Haplogroup, these have not been "traditionally considered admixed with mainstream Jewish populations" – the frequency of the J1 Haplogroup is the following: Yemen (34.2%), Oman (22.8%), Negev (21.9%), and Iraq (19.2%); and amongst Muslim Kurds (22.1%), Bedouins (21.9%), and Armenians (12.7%).[15]

On the other hand, Jewish populations were found to have a "markedly higher" proportion of full 6/6 matches, according to the same (2005) meta-analysis,[15] this was compared to these non-Jewish populations, where "individuals matching at only 5/6 markers are most commonly observed."[15]

The authors Elkins, et al. warned in their report that "using the current CMH definition to a infer relation of individuals or groups to the Kohen or ancient Hebrew populations would produce many false-positive results," and note that "it is possible that the originally defined CMH represents a slight permutation of a more general Middle Eastern type that was established early on in the population prior to the divergence of haplogroup J. Under such conditions, parallel convergence in divergent clades to the same STR haplotype would be possible."[15]

Cadenas et al. analysed Y-DNA patterns from around the Gulf of Oman in more detail in 2007.[16] The detailed data confirm that the main cluster of haplogroup J1 haplotypes from the Yemeni appears to be some genetic distance from the CMH-12 pattern typical of eastern European Ashkenazi Kohanim, but not of Sephardic Kohanim.

Multiple ancestries[edit]

Even within the Jewish Kohen population, it became clear that there were multiple Kohen lineages, including distinctive lineages both in Haplogroup J1 and in haplogroup J2.[17] Other groups of Jewish lineages (i.e. Jews who are non-kohanim) were found in Haplogroup J2 that matched the original 6-marker CMH, but which were unrelated and not associated with Kohanim. Current estimates,[citation needed] based on the accumulation of SNP mutations, place the defining mutations that distinguish haplogroups J1 and J2 as having occurred about 20 to 30,000 years ago.

Subsequent studies[edit]

In response to the low resolution of the original 6-marker CMH, the testing company FTDNA released a 12-marker CMH signature that was more specific to the large, closely related group of Kohanim in Haplogroup J1.

A 2009 academic study by Michael F. Hammer, Doron M. Behar, et al. examined more STR markers in order to sharpen the "resolution" of these Kohanim genetic markers, thus separating both Ashkenazi and other Jewish Kohanim from other populations, and identifying a more sharply defined SNP haplogroup, J1e* (now J1c3, also called J-P58*) for the J1 lineage. The research found "that 46.1% of Kohanim carry Y chromosomes belonging to a single paternal lineage (J-P58*) that likely originated in the Near East well before the dispersal of Jewish groups in the Diaspora. Support for a Near Eastern origin of this lineage comes from its high frequency in our sample of Bedouins, Yemenis (67%), and Jordanians (55%) and its precipitous drop in frequency as one moves away from Saudi Arabia and the Near East (Fig. 4). Moreover, there is a striking contrast between the relatively high frequency of J-58* in Jewish populations (»20%) and Kohanim (»46%) and its vanishingly low frequency in our sample of non-Jewish populations that hosted Jewish diaspora communities outside of the Near East."[18] The authors state, in their "Abstract" to the article:

"These results support the hypothesis of a common origin of the CMH in the Near East well before the dispersion of the Jewish people into separate communities, and indicate that the majority of contemporary Jewish priests descend from a limited number of paternal lineages."

Recent phylogenetic research for haplogroup J-M267 placed the "Extended Cohen Modal Haplotype" in a subhaplogroup of J-L862,L147.1 (age estimate 5631-6778yBP yBP): YSC235>PF4847/CTS11741>YSC234>ZS241>ZS227>Z18271 (age estimate 2731yBP).[2]

A 2014 article analysing earlier research attempting to trace Jewish ancestry (not just of the Lemba) states:

In conclusion, while the observed distribution of sub-clades of haplotypes at mitochondrial and Y chromosome non-recombinant genomes might be compatible with founder events in recent times at the origin of Jewish groups as Cohenite, Levite, Ashkenazite, the overall substantial polyphyletism as well as their systematic occurrence in non-Jewish groups highlights the lack of support for using them either as markers of Jewish ancestry or Biblical tales.

— [19]

Kohanim in other haplogroups[edit]

Behar's 2003 data[5] point to the following Haplogroup distribution for Ashkenazi Kohanim (AC) and Sephardic Kohanim (SC) as a whole:

Hg: E3b G2c H I1b J K2 Q R1a1 R1b Total
AC 3 0 1 0 67 2 0 1 2 76
4% 1½% 88% 2½% 1½% 2½% 100%
SC 3 1 0 1 52 2 2 3 4 68
4½% 1½% 1½% 76% 3% 3% 4½% 6% 100%

The detailed breakdown by 6-marker haplotype (the paper's Table B, available only online) suggests that at least some of these groups (e.g. E3b, R1b) contain more than one distinct Kohen lineage, it is possible that other lineages may also exist, but were not captured in the sample.

Hammer et al. (2009) identified Cohanim from diverse backgrounds, having in all 21 differing Y-chromosome haplogroups: E-M78, E-M123, G-M285, G-P15, G-M377, H-M69, I-M253, J-P58, J-M172*, J-M410*, J-M67, J-M68, J-M318, J-M12, L-M20, Q-M378, R-M17, R-P25*, R-M269, R-M124 AND T-M70.[18]

Y-chromosomal Levi[edit]

Similar investigation was made of men who identify as Levites, the priestly Kohanim are believed to have descended from Aaron (among those who believe he was a historical figure). He was a descendant of Levi, son of Jacob, the Levites comprised a lower rank of the Temple than the priests. They are considered descendants of Levi through other lineages. Levites should also therefore share common Y-chromosomal DNA.

The investigation of Levites found high frequencies of multiple distinct markers, suggestive of multiple origins for the majority of non-Aaronid Levite families. One marker, however, present in more than 50% of Eastern European (Ashkenazi) Jewish Levites, points to a common male ancestor or very few male ancestors within the last 2000 years for many Levites of the Ashkenazi community, this common ancestor belonged to the haplogroup R1a1, which is typical of Eastern Europeans or West Asians, rather than the haplogroup J of the Cohen modal haplotype. The ancestor(s) most likely lived at the time of the Ashkenazi settlement in Eastern Europe, and would thus be considered founders of this line.[5][20][21] He or they were unlikely to have descended from Levites.

But, a study published online in Nature Communications in December 2013 disputes this conclusion. Based on its research into 16 whole R1 sequences, the team determined that a set of 19 unique nucleotide substitutions defines the Ashkenazi R1a lineage. One of these, the M582 mutation, is not widely found among Eastern Europeans, but this marker was present "in all sampled R1a Ashkenazi Levites, as well as in 33.8% of other R1a Ashkenazi Jewish males, and 5.9% of 303 R1a Near Eastern males, where it shows considerably higher diversity." [22] Rootsi, Behar, et al., concluded that this marker most likely originates in the pre-Diasporic Hebrews in the Near East.[22]

The E1b1b1 haplogroup (formerly known as E3b1) has been observed in all Jewish groups worldwide, after the J halogroups, it is considered to be the second-most prevalent haplogroup among the Jewish populations.

Samaritan Kohanim[edit]

The Samaritan community in the Middle East survives as a distinct religious and cultural sect, it constitutes one of the oldest and smallest ethnic minorities in the world, numbering sightly less than 800 members. According to Jewish accounts, the Samaritans broke away from the mainstream Israelites as a religious sect around the eighth century B.C. According to Samaritan accounts, it was the southern tribes of the House of Judah who left the original worship as set forth by Joshua, and the schism took place in the twelfth century B.C. at the time of Eli.[23] The Samaritans have maintained their religion and history to this day, and claim to be the remnant of the House of Israel, specifically of the tribes of Ephraim and Manasseh with priests of the line of Aaron/Levi.

Since the Samaritans have maintained extensive and detailed genealogical records for the past 13–15 generations (approximately 400 years) and further back, researchers have constructed accurate pedigrees and specific maternal and paternal lineages. A 2004 Y-Chromosome study concluded that the majority of Samaritans belong to haplogroups J1 and J2, while the Samaritan Kohanim belong to haplogroup E1b1b1a (formerly known as E3b1a).[24]

"The Samaritan M267 lineages differed from the classical Cohen modal haplotype at DYS391, carrying 11 rather than 10 repeats", as well as, have a completely different haplogroup, which should have been "J1". Samaritan Kohanim descend from a different patrilineal family line, having haplogroup E1b1b1a (M78) (formerly E3b1a).[24]

See also[edit]

References[edit]

  1. ^ a b c d e Thomas, MG; Skorecki K; Ben-Ami H; Parfitt T; Bradman N; Goldstein DB (1998). "Origins of Old Testament priests" (PDF). Nature. 394 (6689): 138–40. doi:10.1038/28083. PMID 9671297. 
  2. ^ a b c Mas, V. (2013). "Y-DNA Haplogroup J1 phylogenetic tree". doi:10.6084/m9.figshare.741212. 
  3. ^ a b Academia, J1 (2016). "Origins and history of Haplogroup j1". 
  4. ^ a b Skorecki, K; Selig, S.; Blazer, S.; Bradman, R.; Bradman, N.; Waburton, P.J.; Ismajlowicz, M.; Hammer M.F. (1997). "Y chromosomes of Jewish priests". Nature. 385 (6611): 32. doi:10.1038/385032a0. PMID 8985243. 
  5. ^ a b c d Behar, DM; Thomas, MG; Skorecki, K; Hammer, MF; Bulygina, E; Rosengarten, D; Jones, AL; Held, K; Moses, V; Goldstein, D; Bradman, N; Weale, ME (October 2003). "Multiple Origins of Ashkenazi Levites: Y Chromosome Evidence for Both Near Eastern and European Ancestries". American Journal of Human Genetics. 73 (4): 768–79. doi:10.1086/378506. PMC 1180600Freely accessible. PMID 13680527. 
  6. ^ Kleiman, Rabbi Yaakov (2000). "The Cohanim/DNA connection". 
  7. ^ Clark, David (2002). "Cohanim Modal Haplotype (CMH) finds the Ten Lost Tribes! (among Iraqi Kurds, Hungarians, and Armenians)". Archived from the original on 22 March 2005. 
  8. ^ Thomas, MG; Parfitt T; Weiss DA; Skorecki K; Wilson JF; le Roux M; Bradman N; Goldstein DB (2000). "Y Chromosomes Traveling South: The Cohen Modal Haplotype and the Origins of the Lemba—the "Black Jews of Southern Africa"". American Journal of Human Genetics. 66 (2): 674–86. doi:10.1086/302749. PMC 1288118Freely accessible. PMID 10677325. 
  9. ^ Himla Soodyall; Jennifer G. R Kromberg. "Human Genetics and Genomics and Sociocultural Beliefs and Practices in South Africa". In Kumar, Dhavendra; Chadwick, Ruth. Genomics and Society: Ethical, Legal, Cultural and Socioeconomic Implications. Academic Press/Elsevier. p. 316. ISBN 978-0-12-420195-8. 
  10. ^ Soodyal, H (2013). "Lemba origins revisited: Tracing the ancestry of Y chromosomes in South African and Zimbabwean Lemba". South African Medical Journal. 103 (12). Retrieved 9 May 2014. 
  11. ^ Tofanelli Sergio, Taglioli Luca, Bertoncini Stefania, Francalacci Paolo, Klyosov Anatole, Pagani Luca, "Mitochondrial and Y chromosome haplotype motifs as diagnostic markers of Jewish ancestry: a reconsideration", Frontiers in Genetics Volume 5, 2014, [1] DOI=10.3389/fgene.2014.00384
  12. ^ Zoossmann-Diskin, Avshalom (2001). "Are today's Jewish priests descended from the old ones?". Journal of Comparative Human Biology. 51 (2–3): 156–162.  (Summary)
  13. ^ Nebel, A; Filon D; Brinkmann B; Majumder PP; Faerman M; Oppenheim A (November 2001). "The Y Chromosome Pool of Jews as Part of the Genetic Landscape of the Middle East". American Journal of Human Genetics. 69 (5): 1095–112. doi:10.1086/324070. PMC 1274378Freely accessible. PMID 11573163. [dead link]
  14. ^ Semino, O; Magri, C; Benuzzi, G; Lin, AA; Al-Zahery, N; Battaglia, V; Maccioni, L; Triantaphyllidis, C; Shen, P; Oefner, PJ; Zhivotovsky, LA; King, R; Torroni, A; Cavalli-Sforza, LL; Underhill, PA; Santachiara-Benerecetti, AS (May 2004). "Origin, Diffusion, and Differentiation of Y-Chromosome Haplogroups E and J: Inferences on the Neolithization of Europe and Later Migratory Events in the Mediterranean Area". American Journal of Human Genetics. 74 (5): 1023–34. doi:10.1086/386295. PMC 1181965Freely accessible. PMID 15069642. 
  15. ^ a b c d Ekins, JE; Tinah, E.N.; Myres, N.M.; Ritchie, K.H.; Perego, U.A.; Ekins, J.B.; Hutchison, L.A.D.; Layton, L.; Lunt, M.L.; Masek, S.S.; Nelson, A.A.; Nelson, M.E.; Pennington, K.L.; Peterson, J.L.; Tolley, T.; Woodward, S.R. (2005). "An Updated World-Wide Characterization of the Cohen Modal Haplotype" (PDF). ASHG meeting October 2005. 
  16. ^ Cadenas, AM; Zhivotovsky LA; Cavalli-Sforza LL; Underhill PA; Herrera RJ (2008). "Y-chromosome diversity characterizes the Gulf of Oman". European Journal of Human Genetics. 16 (3): 374–386. doi:10.1038/sj.ejhg.5201934. PMID 17928816. 
  17. ^ Malaspina, P.; Tsopanomichalou, M.; Duman, T.; Stefan, M.; Silvestri, A.; Rinaldi, B.; Garcia, O.; Giparaki, M.; Plata, E.; Kozlov, A.I.; Barbujani, G.; Vernesi, C.; Papola, F.; Ciavarella, G.; Kovatchev, D.; Kerimova, M.G.; Anagnou, N.; Gavrila, L.; Veneziano, L.; Akar, N.; Loutradis, A.; Michalodimitrakis, E.N.; Terrenato, L.; Novelletto, A. (July 2001). "A multistep process for the dispersal of a Y chromosomal lineage in the Mediterranean area". Annals of Human Genetics. 65 (4): 339–49. doi:10.1046/j.1469-1809.2001.6540339.x. PMID 11592923. 
    Confusingly, because only four of the markers that Malaspina et al. tested were markers in common with the CMH study, three of which matched, they originally concluded that all of the CMH matches should be identified with what is now called Haplogroup J2. This is now known not to be the case.
  18. ^ a b Hammer, Michael F; Behar, Doron M.; et al. (8 August 2009). "Extended Y chromosome haplotypes resolve multiple and unique lineages of the Jewish priesthood". Human Genetics. 126 (5): 707–717. doi:10.1007/s00439-009-0727-5. PMC 2771134Freely accessible. PMID 19669163. 
  19. ^ Tofanelli Sergio, Taglioli Luca, Bertoncini Stefania, Francalacci Paolo, Klyosov Anatole, Pagani Luca, "Mitochondrial and Y chromosome haplotype motifs as diagnostic markers of Jewish ancestry: a reconsideration", Frontiers in Genetics Volume 5, 2014, [2] DOI=10.3389/fgene.2014.00384
  20. ^ Behar, DM; Garrigan D; Kaplan ME; Mobasher Z; Rosengarten D; Karafet TM; Quintana-Murci L; Ostrer H; Skorecki K; Hammer MF (2004). "Contrasting patterns of Y chromosome variation in Ashkenazi Jewish and host non-Jewish European populations" (PDF). Human Genetics. 114 (4): 354–365. doi:10.1007/s00439-003-1073-7. PMID 14740294. 
  21. ^ Nebel, A; Filon D; Faerman M; Soodyall H; Oppenheim A (2004). "Y chromosome evidence for a founder effect in Ashkenazi Jews". European Journal of Human Genetics. 13 (3): 388–91. doi:10.1038/sj.ejhg.5201319. PMID 15523495. 
  22. ^ a b Siiri Rootsi, Doron M. Behar, et al., "Eastern origin of Ashkenazi Levites", Nature Communications 4, Article number: 2928 (2013) doi:10.1038/ncomms3928, published online 13 December 2013; accessed 4 October 2016
  23. ^ Brindle, Wayne (1984). "The Origin and History of the Samaritans". 
  24. ^ a b Shen, P; Lavi T; Kivisild T; Chou V; Sengun D; Gefel D; Shpirer I; Woolf E; Hillel J; Feldman MW; Oefner PJ (2004). "Reconstruction of Patrilineages and Matrilineages of Samaritans and Other Israeli Populations From Y-Chromosome and Mitochondrial DNA Sequence Variation" (PDF). Human Mutation. 24 (3): 248–260. doi:10.1002/humu.20077. PMID 15300852. 

External links[edit]