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Cartoon depiction of the protein Streptococcus pyogenes family GH38 α-Mannosidase created using PyMol.[1][2]
alpha-mannosidase 1, tetramer, Saccharomyces cerevisiae
EC number
CAS number 9025-42-7
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

alpha-Mannosidase (EC, alpha-D-mannosidase, p-nitrophenyl-alpha-mannosidase, alpha-D-mannopyranosidase, 1,2-alpha-mannosidase, 1,2-alpha-D-mannosidase, exo-alpha-mannosidase) is an enzyme involved in the cleavage of the alpha form of mannose. Its systematic name is alpha-D-mannoside mannohydrolase.[3][4]


Humans express the following three alpha-mannosidase isozymes:

mannosidase, alpha, class 2B, member 1
Symbol MAN2B1
Alt. symbols MANB
Entrez 4125
HUGO 6826
OMIM 609458
RefSeq NM_000528
UniProt O00754
Other data
EC number
Locus Chr. 19 cen-q13.1
mannosidase, alpha, class 2B, member 2
Symbol MAN2B2
Alt. symbols KIAA0935
Entrez 23324
HUGO 29623
RefSeq NM_015274
UniProt Q9Y2E5
Other data
EC number
Locus Chr. 4 p16.2
mannosidase, alpha, class 2C, member 1
Symbol MAN2C1
Alt. symbols MANA1, MANA
Entrez 4123
HUGO 6827
OMIM 154580
RefSeq NM_006715
UniProt Q9NTJ4
Other data
EC number
Locus Chr. 15 q11-qter


It can be utilized in experiments that determine the effects of the presence or absence of mannose on specific molecules, such as recombinant proteins that are used in vaccine development.[5]


A deficiency can lead to alpha-mannosidosis.[6]


  1. ^ "PyMol". Schrodinger. Retrieved 2011-09-14. 
  2. ^ Suits, MDL; Yanping Zhu; Edward J. Taylor; Julia Walton; David L. Zechel; Harry J. Gilbert; Gideon J. Davies (3 February 2010). "Structure and Kinetic Investigation of Streptococcus pyogenes Family GH38 α-Mannosidase". PLoS ONE. 5 (2). doi:10.1371/journal.pone.0009006. Retrieved 2011-09-14. 
  3. ^ Li, Y.-T. (1966). "Presence of α-D-mannosidic linkage in glycoproteins. Liberation of D-mannose from various glycoproteins by α-mannosidase isolated from jack bean meal". J. Biol. Chem. 241 (4): 1010–1012. PMID 5905120. 
  4. ^ Winchester, B. (1984). "Role of α-D-mannosidases in the biosynthesis and catabolism of glycoproteins". Biochem. Soc. Trans. 12 (3): 522–524. PMID 6428944. 
  5. ^ Vlahopoulos S, Gritzapis AD, Perez SA, Cacoullos N, Papamichail M, Baxevanis CN (2009). "Mannose addition by yeast Pichia Pastoris on recombinant HER-2 protein inhibits recognition by the monoclonal antibody herceptin". Vaccine. 27 (34): 4704–8. doi:10.1016/j.vaccine.2009.05.063. PMID 19520203. 
  6. ^ Malm D, Nilssen Ø (2008). "Alpha-mannosidosis". Orphanet J Rare Dis. 3: 21. doi:10.1186/1750-1172-3-21. PMC 2515294Freely accessible. PMID 18651971. 

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