The 1880 Democratic National Convention was held June 22 to 24, 1880, at the Music Hall in Cincinnati, Ohio, and nominated Winfield S. Hancock of Pennsylvania for president and William H. English of Indiana for vice president in the United States presidential election of 1880.

Winfield Scott Hancock was a United States Army officer and the Democratic nominee for President of the United States in 1880. He served with distinction in the Army for four decades, including service in the Mexican–American War and as a Union general in the American Civil War. Known to his Army colleagues as "Hancock the Superb," he was noted in particular for his personal leadership at the Battle of Gettysburg in 1863. His military service continued after the Civil War, as Hancock participated in the military Reconstruction of the South and the U.S.'s western expansion and war with the Native Americans at the Western frontier. This concluded with the Medicine Lodge Treaty. From 1881 to 1885 he was president of the Aztec Club of 1847 for veteran officers of the Mexican-American War.