The 1880 Republican National Convention convened from June 2 to June 8, 1880, at the Interstate Exposition Building in Chicago, Illinois, United States. Delegates nominated James A. Garfield of Ohio and Chester A. Arthur of New York as the official Republican Party candidates for president and vice president in the 1880 presidential election.

James Abram Garfield was the 20th president of the United States, serving from March 1881 until his death the following September after being shot by an assassin in July. A preacher, lawyer, and Civil War general, Garfield served nine terms in the United States House of Representatives and is the only sitting member of the House to be elected president. Before his candidacy for the presidency, he had been elected to the U.S. Senate by the Ohio General Assembly—a position he declined when he became president-elect.