The 1888 Republican National Convention was a presidential nominating convention held at the Auditorium Building in Chicago, Illinois, on June 19–25, 1888. It resulted in the nomination of former Senator Benjamin Harrison of Indiana for president and Levi P. Morton of New York, a former Representative and Minister to France, for vice president. During the convention, Frederick Douglass was invited to speak and became the first African-American to have his name put forward for a presidential nomination in a major party's roll call vote; he received one vote from Kentucky on the fourth ballot.

The Auditorium Building in Chicago is one of the best-known designs of Louis Sullivan and Dankmar Adler. Completed in 1889, the building is located at the northwest corner of South Michigan Avenue and Ida B. Wells Drive. The building was designed to be a multi-use complex, including offices, a theater, and a hotel. As a young apprentice, Frank Lloyd Wright worked on some of the interior design.