The 1981 Argentine Grand Prix was the third race of the 1981 Formula One World Championship and was held at the Buenos Aires circuit in Argentina on 12 April 1981. This was the last Argentine Grand Prix until 1995. Thanks to designer Gordon Murray's alternative solution to flexible side skirts, the Brabham cars of Nelson Piquet and Héctor Rebaque were dominant in this race, with Piquet taking the lead immediately from Alan Jones on the back straight and Rebaque climbing up from 5th to 2nd over 23 laps.

Nelson Piquet Souto Maior is a Brazilian retired racing driver and businessman who won the World Drivers' Championship three times in the years 1981, 1983 and 1987.