The 1981 Giro d'Italia was the 64th running of the Giro. It started in Brescia, on 13 May, with a 6.6 km (4.1 mi) prologue and concluded in Verona, on 7 June, with a 42 km (26.1 mi) individual time trial. A total of 130 riders from thirteen teams entered the 22-stage race, that was won by Italian Giovanni Battaglin of the Inoxpran team. The second and third places were taken by Swede Tommy Prim and Italian Giuseppe Saronni, respectively.

Giovanni Battaglin is an Italian professional road racing cyclist. The highlight of his career was his overall win in the 1981 Giro d'Italia. He also won the 1981 Vuelta a España.