The 1995 American League Championship Series (ALCS), the second round of the 1995 American League playoffs, matched the Central Division champion Cleveland Indians against the West Division champion Seattle Mariners. The Mariners had the home field advantage, which was predetermined and assigned to either the West Division champion or their opponents in the Division Series.

The American League Championship Series (ALCS), also known as the American League Pennant, is a best-of-seven playoff and one of two League Championship Series comprising the penultimate round of Major League Baseball's (MLB) postseason. The winner of the ALCS wins the AL pennant and advances to the World Series, MLB's championship series, to play the winner of the National League's (NL) Championship Series. The ALCS began in 1969 as a best-of-five playoff and used this format until 1985, when it changed to its current best-of-seven format.