The 1999 Giro d'Italia was the 82nd edition of the Giro. It began on May 15 with a mass-start stage that stretched from Agrigento to Modica. The race came to a close on June 6 with a mass-start stage that ended in the Italian city of Milan. Eighteen teams entered the race that was won by the Italian Ivan Gotti of the Team Polti team. Second and third were the Italians riders Paolo Savoldelli and Gilberto Simoni. Marco Pantani is credited with four high mountain stage victories.

The Giro d'Italia is an annual multiple-stage bicycle race primarily held in Italy, while also starting in, or passing through, other countries. The first race was organized in 1909 to increase sales of the newspaper La Gazzetta dello Sport, and the race is still run by a subsidiary of that paper's owner. The race has been held annually since its first edition in 1909, except during the two world wars. As the Giro gained prominence and popularity the race was lengthened, and the peloton expanded from primarily Italian participation to riders from all over the world. The Giro is a UCI World Tour event, which means that the teams that compete in the race are mostly UCI WorldTeams, with some additional teams invited as 'wild cards'.