The 2006 Malaysian Grand Prix was a Formula One motor race held at the Sepang International Circuit in Selangor, Malaysia on 19 March 2006. The 56-lap race was the second round of the 2006 Formula One season and the eighth running of the Malaysian Grand Prix as a World Championship race. It was won by Renault driver Giancarlo Fisichella, who took the final of his three victories in Formula One, and scored his first points of the season. He had also started on pole position. His team-mate, Fernando Alonso, finished second to extend his lead in the drivers' championship standings to 7 points. Jenson Button took the first podium in Honda's three year return to the sport by finishing in third place. Fisichella's victory was the last for an Italian driver as of 2023. This was the first 1-2 finish for Renault since their return to F1 as a constructor in 2002, and also their first 1-2 finish overall since the 1982 French Grand Prix.

Renault, a French automobile manufacturer, has been associated with Formula One as both team owner and engine manufacturer for various periods since 1977. In 1977, the company entered Formula One as a constructor, introducing the turbo engine to Formula One with its EF1 engine. In 1983, Renault began supplying engines to other teams. Although the Renault team had won races, it withdrew at the end of 1985. Renault engines continued to be raced until 1986.