The 2010 Africa Cup of Nations, also known as the Orange Africa Cup of Nations for sponsorship reasons, was the 27th Africa Cup of Nations, the biennial football championship of Africa (CAF). It was held in Angola, where it began on 10 January 2010 and concluded on 31 January.

The Africa Cup of Nations commonly referred to as the TotalEnergies Africa Cup of Nations for sponsorship reasons, or simply AFCON or CAN, is the main international men's association football competition in Africa. It is sanctioned by the Confederation of African Football (CAF) and was first held in 1957. Since 1968, it has been held every two years, switching to odd-numbered years in 2013.