The 2010 Nevada Wolf Pack football team represented the University of Nevada, Reno in the 2010 NCAA Division I FBS football season. The Wolf Pack were led by Chris Ault in his 26th overall and 7th straight season since taking over as head coach for the third time in 2004. They played their home games at Mackay Stadium and were members of the Western Athletic Conference (WAC). They finished the regular season 12–1 and 7–1 in WAC play to share the conference championship with Boise State and Hawaii. They were invited to the Kraft Fight Hunger Bowl where they defeated Boston College 20–13 to finish the season with a 13–1 record.

The 2010 NCAA Division I FBS football season was the highest level of college football competition in the United States organized by the National Collegiate Athletic Association (NCAA).