The 27th Independent Spirit Awards, honoring the best independent films of 2011, were presented on February 25, 2012. The nominations were announced on November 29, 2011. The ceremony was hosted by Seth Rogen and aired exclusively on IFC. Highlights included John Waters as the "Voice of God", and musical performances by My Morning Jacket and K'naan.

Seth Aaron Rogen is a Canadian-American actor, comedian and filmmaker. Originally a stand-up comedian in Vancouver, he moved to Los Angeles for a part in Judd Apatow's series Freaks and Geeks in 1999, and got a part on Apatow's sitcom Undeclared in 2001, which also hired him as a writer. Rogen landed a job as a staff writer on the final season of Da Ali G Show (2004), for which the writing team was nominated for a Primetime Emmy Award for Outstanding Writing for a Variety Series. Apatow subsequently guided him toward a film career.