The 2nd Infantry Regiment is an infantry regiment in the United States Army that has served for more than two hundred years. It was constituted on 12 April 1808 as the 6th Infantry and consolidated with 4 other regiments in 1815 to form the present unit.

Fort Yuma was a fort in California located in Imperial County, across the Colorado River from Yuma, Arizona. It was Established in 1848. It served as a stop on the Butterfield Overland Mail route from 1858 until 1861. The fort was retired from active military service on May 16, 1883, and transferred to the Department of the Interior. The Fort Yuma Indian School and the Saint Thomas Yuma Indian Mission now occupy the site. It is one of the "associated sites" listed as Yuma Crossing and Associated Sites on the National Register of Historic Places in the Yuma Crossing National Heritage Area. In addition, it is registered as California Historical Landmark #806.