The 7th Cavalry Regiment is a United States Army cavalry regiment formed in 1866. Its official nickname is "Garryowen", after the Irish air "Garryowen" that was adopted as its march tune. The regiment participated in some of the largest battles of the Indian Wars, including its famous defeat at the Battle of Little Bighorn, where its commander Lieutenant Colonel George A. Custer was killed.

The Battle of the Little Bighorn, known to the Lakota and other Plains Indians as the Battle of the Greasy Grass, and commonly referred to as Custer's Last Stand, was an armed engagement between combined forces of the Lakota Sioux, Northern Cheyenne, and Arapaho tribes and the 7th Cavalry Regiment of the United States Army. The battle, which resulted in the defeat of U.S. forces, was the most significant action of the Great Sioux War of 1876. It took place on June 25–26, 1876, along the Little Bighorn River in the Crow Indian Reservation in southeastern Montana Territory.