According to ancient and medieval science, aether, also known as the fifth element or quintessence, is the material that fills the region of the universe beyond the terrestrial sphere. The concept of aether was used in several theories to explain several natural phenomena, such as the propagation of light and gravity. In the late 19th century, physicists postulated that aether permeated space, providing a medium through which light could travel in a vacuum, but evidence for the presence of such a medium was not found in the Michelson–Morley experiment, and this result has been interpreted to mean that no luminiferous aether exists.

A vacuum is space devoid of matter. The word is derived from the Latin adjective vacuus meaning "vacant" or "void". An approximation to such vacuum is a region with a gaseous pressure much less than atmospheric pressure. Physicists often discuss ideal test results that would occur in a perfect vacuum, which they sometimes simply call "vacuum" or free space, and use the term partial vacuum to refer to an actual imperfect vacuum as one might have in a laboratory or in space. In engineering and applied physics on the other hand, vacuum refers to any space in which the pressure is considerably lower than atmospheric pressure. The Latin term in vacuo is used to describe an object that is surrounded by a vacuum.