Ambon Island is part of the Maluku Islands of Indonesia. The island has an area of 743.37 km2 (287.02 sq mi) and is mountainous, well watered, and fertile. Ambon Island consists of two territories: the city of Ambon to the south and various districts (kecamatan) of the Central Maluku Regency to the north. The main city and seaport is Ambon, which is also the capital of Maluku province, while those districts of Maluku Tengah Regency situated on Ambon Island had a 2020 Census population of 128,069. By mid 2023 those populations were estimated to have become 354,052 and 128,754 respectively, resulting in an all-island population of 482,806.

The Maluku Islands or the Moluccas are an archipelago in the eastern part of Indonesia. Tectonically they are located on the Halmahera Plate within the Molucca Sea Collision Zone. Geographically they are located east of Sulawesi, west of New Guinea, and north and east of Timor. Lying within Wallacea, the Moluccas have been considered a geographical and cultural intersection of Asia and Oceania.