The Andohahela National Park is situated in Anosy in the south-east of Madagascar. It is remarkable for the extremes of habitats that are represented within it. The park covers 760 km2 (293 sq mi) of the Anosy mountain range, the southernmost spur of the Malagasy Highlands and contains the last humid rainforests in the southern part of Madagascar.

Anosy is one of the 22 regions of Madagascar. It is located in the southeast of the country, on the eastern side of what was once the Toliara Province. The name Anosy means "island(s)" in Malagasy.