Anna of Saxony was the heiress of Maurice, Elector of Saxony, and Agnes, eldest daughter of Philip I, Landgrave of Hesse. Maurice's only son, Albert, died in infancy. Anna was the second wife of William the Silent.

Maurice was Duke (1541–47) and later Elector (1547–53) of Saxony. His clever manipulation of alliances and disputes gained the Albertine branch of the Wettin dynasty extensive lands and the electoral dignity.