Apollo 17 was the eleventh and final mission of NASA's Apollo program, the sixth and most recent time humans have set foot on the Moon or traveled beyond low Earth orbit. Commander Gene Cernan and Lunar Module Pilot Harrison Schmitt walked on the Moon, while Command Module Pilot Ronald Evans orbited above. Schmitt was the only professional geologist to land on the Moon; he was selected in place of Joe Engle, as NASA had been under pressure to send a scientist to the Moon. The mission's heavy emphasis on science meant the inclusion of a number of new experiments, including a biological experiment containing five mice that was carried in the command module.

The National Aeronautics and Space Administration is an independent agency of the U.S. federal government responsible for the civil space program, aeronautics research, and space research. Established in 1958, it succeeded the National Advisory Committee for Aeronautics (NACA) to give the U.S. space development effort a distinct civilian orientation, emphasizing peaceful applications in space science. It has since led most of America's space exploration programs, including Project Mercury, Project Gemini, the 1968–1972 Apollo Moon landing missions, the Skylab space station, and the Space Shuttle. Currently, NASA supports the International Space Station along with the Commercial Crew Program, and oversees the development of the Orion spacecraft and the Space Launch System for the lunar Artemis program.