The Arghun dynasty ruled over the area adjoining Southern Afghanistan and then the Sindh Sultanate from the late 15th century to the early 16th century. Arghun rule can be divided into two branches: the Arghun branch of Dhu'l-Nun Beg Arghun that ruled until 1554, and the Tarkhan branch of Muhammad Isa Tarkhan that ruled until 1593.

Kandahar is a city in Afghanistan, located in the south of the country on the Arghandab River, at an elevation of 1,010 m (3,310 ft). It is Afghanistan's second largest city after Kabul, with a population of about 614,118. It is the capital of Kandahar Province and the centre of the larger cultural region called Loy Kandahar. Kandahar is the founding city and spiritual center of the Taliban. Despite the capital of Afghanistan being Kabul, where the government administration is based, Kandahar is the seat of power in Afghanistan as the supreme leader and his spiritual advisers are based there. Kandahar has therefore been called the de facto capital of Afghanistan, though the Taliban maintain Kabul is the capital.