Highway 265 is a designation for three state highways in Northwest Arkansas. The southern segment of 19.70 miles (31.70 km) runs from Highway 170 near Strickler north to I-49/US 71/Highway 112 in south Fayetteville. A second segment begins in east Fayetteville at Highway 16 and runs north through Springdale to Highway 94 in Rogers. Further north, a third segment of 3.324 miles (5.349 km) runs from Highway 94 in Pea Ridge north to the Missouri state line. The highways are maintained by the Arkansas Department of Transportation (ARDOT).

Interstate 49 (I-49) is an Interstate Highway in the state of Arkansas. There are two main sections of the highway across different sides of the state. The southern section starts at the Louisiana state line, then runs to Texarkana, at the Texas state line. The northern section begins at I-40 and at U.S. Highway 71 (US 71) in Alma and runs north to the Missouri state line, where the freeway continues into Missouri. An additional small section south of Fort Smith is currently designated as Highway 549 until it is extended northward to the I-40 interchange, at which point it will become part of I-49.