Babylon was an ancient city located on the lower Euphrates river in southern Mesopotamia, within modern-day Hillah, Babil Governorate, Iraq about 85 kilometers south of modern day Baghdad. Babylon functioned as the main cultural and political centre of the Akkadian-speaking region of Babylonia. Its rulers establishing two important empires in antiquity, the 19th–16th century BC Old Babylonian Empire, and the 7th–6th century BC Neo-Babylonian Empire. Babylon was also used as a regional capital of other empires, such as the Achaemenid Empire. Babylon was one of the most important urban centres of the ancient Near East, until its decline during the Hellenistic period. Nearby ancient sites are Kish, Borsippa, Dilbat, and Kutha.

In classical antiquity, the Hellenistic period covers the time in Mediterranean history after Classical Greece, between the death of Alexander the Great in 323 BC and the death of Cleopatra VII, followed by the emergence of the Roman Empire, as signified by the Battle of Actium in 31 BC and the conquest of Ptolemaic Egypt the following year. The Ancient Greek word Hellas was gradually recognized as the name for Greece, from which the word Hellenistic was derived. "Hellenistic" is distinguished from "Hellenic" in that the latter refers to Greece itself, while the former encompasses all ancient territories under Greek influence, in particular the East after the conquests of Alexander the Great.