Muhammad Bairam Khan, commonly known as Bairam Khan or Bayram Khan was an important military commander, and later commander-in-chief of the Mughal army, a powerful statesman and regent at the court of the Mughal Emperors, Humayun and Akbar. He was also the guardian, chief mentor, adviser, teacher and the most trusted ally of Akbar. Akbar honoured him as Khan-i-Khanan, which means "King of Kings". Bairam was originally called Bairam "Beg", but later became honoured as Khan. Bairam Khan was an aggressive general who was determined to restore Mughal authority in India.

The Mughal Empire was an early modern Indo-Muslim empire in South Asia. At its peak, the empire stretched from the outer fringes of the Indus River Basin in the west, northern Afghanistan in the northwest, and Kashmir in the north, to the highlands of present-day Assam and Bangladesh in the east, and the uplands of the Deccan Plateau in South India.