Barcelona Sants is the main railway station in Barcelona, owned by Adif, the railway infrastructure agency of Spain. It has become the most important transport hub of the city - being the centre of Rodalies de Catalunya including Barcelona suburban railway services and regional services, as well as the main inter-city station for national and international destinations. The station is named after Sants, the neighbourhood of Barcelona in which it is located. New parts of the station have recently been remodeled to accommodate the Spanish high-speed train AVE in the city, which started serving the city on 20 February 2008. There is also an adjacent international bus station bearing the same name, and a link to the Sants Estació metro station that serves the railway station.

Rodalies de Catalunya is the main commuter and regional rail system in the Spanish autonomous community of Catalonia. It is administered by the Government of Catalonia and operated by the national rail operator Renfe Operadora. The system consists of 17 service lines chiefly centred in the Barcelona area, serving a total of 203 stations throughout Catalonia, with an average number of 1,000 trains running on it every day. In 2016, it had an annual ridership of 117 million.