The Battle of Anghiari was fought on 29 June 1440, between the forces of Milan and the League of some Italian states led by the Republic of Florence in the course of the Wars in Lombardy. The battle was a victory for the Florentines, who secured their domination of central Italy.

The Republic of Florence, known officially as the Florentine Republic, was a medieval and early modern state that was centered on the Italian city of Florence in Tuscany, Italy. The republic originated in 1115, when the Florentine people rebelled against the Margraviate of Tuscany upon the death of Matilda of Tuscany, who controlled vast territories that included Florence. The Florentines formed a commune in her successors' place. The republic was ruled by a council known as the Signoria of Florence. The signoria was chosen by the gonfaloniere, who was elected every two months by Florentine guild members.