The Battle of Blood River was fought on the bank of the Ncome River, in what is today KwaZulu-Natal, South Africa between 464 Voortrekkers ("Pioneers"), led by Andries Pretorius, and an estimated 25,000 to 30,000 Zulu. Estimations of casualties amounted to over 3,000 of King Dingane's soldiers dead, including two Zulu princes competing with Prince Mpande for the Zulu throne. Three Voortrekker commando members were lightly wounded, including Pretorius.The year 1838 was the most difficult period for the Voortrekkers from when they left the Cape Colony, till the end of the Great Trek. They faced many difficulties and much bloodshed before they found freedom and a safe homeland in their Republic of Natalia. This was only achieved after defeating the Zulu Kingdom, at the Battle of Blood River, which took place on Sunday 16 December 1838. This battle would not have taken place if the Zulu King had honoured the agreement that he had made with the Voortrekkers to live together peacefully. The Zulu king knew that they outnumbered the Voortrekkers and decided to overthrow them and that led to the Battle of Blood river.

KwaZulu-Natal is a province of South Africa that was created in 1994 when the government merged the Zulu bantustan of KwaZulu and Natal Province.