Benedict is an unincorporated town and census-designated place in Charles County, Maryland, United States, located on the Patuxent River in southern Maryland. As of the 2010 census, it had a population of 261.

The Patuxent River is a tributary of the Chesapeake Bay in the state of Maryland. There are three main river drainages for central Maryland: the Potomac River to the west passing through Washington, D.C., the Patapsco River to the northeast passing through Baltimore, and the Patuxent River between the two. The 908-square-mile (2,352 km2) Patuxent watershed had a rapidly growing population of 590,769 in 2000. It is the largest and longest river entirely within Maryland, and its watershed is the largest completely within the state.