The John H. Chafee Blackstone River Valley National Heritage Corridor is a National Heritage Corridor dedicated to the history of the early American Industrial Revolution, including mill towns stretching across 25 cities and towns near the river's course in Worcester County, Massachusetts, and Providence County, Rhode Island. It makes up a historical area in the Blackstone Valley and is named for the late US Senator from Rhode Island John Chafee. In 2014, the Blackstone River Valley National Historical Park was created out of a smaller portion of the National Heritage Corridor. The two units now exist as cooperative entities. The organization is headquartered at the building in Whitinsville, MA, which is located at 670 Linwood Ave, Whitinsville, MA 01588.

The Blackstone Valley or Blackstone River Valley is a region of Massachusetts and Rhode Island. It was a major factor in the American Industrial Revolution. It makes up part of the Blackstone River Valley National Heritage Corridor and National Historical Park.