Buffalo Soldiers were United States Army regiments composed primarily of African Americans, formed during the 19th century to serve on the American frontier. On September 21, 1866, the 10th Cavalry Regiment was formed at Fort Leavenworth, Kansas. The nickname "Buffalo Soldiers" was purportedly given to the regiment by Native Americans who fought against them in the American Indian Wars, and the term eventually became synonymous with all of the African American U.S. Army regiments established in 1866, including the 9th Cavalry Regiment, 10th Cavalry Regiment, 24th Infantry Regiment, 25th Infantry Regiment and 38th Infantry Regiment.

The 10th Cavalry Regiment is a unit of the United States Army. Formed as a segregated African-American unit, the 10th Cavalry was one of the original "Buffalo Soldier" regiments in the post–Civil War Regular Army. It served in combat during the Indian Wars in the western United States, the Spanish–American War in Cuba, Philippine–American War and Mexican Revolution. The regiment was trained as a combat unit but later relegated to non-combat duty and served in that capacity in World War II until its deactivation in 1944.