The Cabinet of Antonis Samaras succeeded the Caretaker Cabinet of Panagiotis Pikrammenos after the repeated legislative elections in May and June 2012. It was sworn in on Thursday, 21 June 2012. The former ministries of Shipping, Tourism and Macedonia and Thrace were re-established. The junior coalition partners, PASOK and DIMAR, chose to take a limited role in the cabinet, preferring to be represented by party officials and independent technocrats instead of MPs. Vassilis Rapanos, the prime minister's first choice for finance minister, fell ill before being sworn in, and tendered his resignation on 25 June. Yannis Stournaras was then chosen as the new finance minister on 26 June, and sworn in on 5 July.

Antonis Samaras is a Greek politician who served as 14th Prime Minister of Greece from 2012 to 2015. A member of the New Democracy party, he was its president from 2009 until 2015. Samaras started his national political career as Minister of Finance in 1989; he served as Minister of Foreign Affairs from 1989 to 1992 and Minister of Culture in 2009.