Santiago de Cali, or Cali, is the capital of the Valle del Cauca department, and the most populous city in southwest Colombia, with 2,227,642 residents according to the 2018 census. The city spans 560.3 km2 (216.3 sq mi) with 120.9 km2 (46.7 sq mi) of urban area, making Cali the second-largest city in the country by area and the third most populous after Bogotá and Medellín. As the only major Colombian city with access to the Pacific Coast, Cali is the main urban and economic center in the south of the country, and has one of Colombia's fastest-growing economies. The city was founded on 25 July 1536 by the Spanish explorer Sebastián de Belalcázar.

Valle del Cauca, or Cauca Valley, is a department in western Colombia abutting the Pacific Ocean. Its capital is Santiago de Cali. Other cities such as Buenaventura, Buga, Cartago, Palmira and Tuluá have great economical, political, social and cultural influence on the department's life. Valle del Cauca has the largest number of independent towns with over 100,000 inhabitants in the country, counting six within its borders. Buenaventura has the largest and busiest seaport in Colombia, moving about 8,500,000 tons of merchandise annually.