State Route 82 is a state highway in the U.S. state of California that runs from Interstate 880 (I-880) in San Jose to I-280 in San Francisco following the San Francisco Peninsula. It is the spinal arterial road of the peninsula and runs parallel to the nearby Caltrain line along much of the route. For much of its length, the highway is named El Camino Real and formed part of the historic El Camino Real mission trail. It passes through and near the historic downtowns of many Peninsula cities, including Burlingame, San Mateo, Redwood City, Menlo Park, Palo Alto, Mountain View, Sunnyvale, and Santa Clara, and through some of the most walkable and transit-oriented neighborhoods in the region.

Interstate 880 (I-880) is a north–south auxiliary Interstate Highway in the San Francisco Bay Area of Northern California. It runs from I-280 and State Route 17 (SR 17) in San Jose to I-80 and I-580 in Oakland, running parallel to the eastern shore of San Francisco Bay. For most of its route, I-880 is officially known as the Nimitz Freeway, after World War II fleet admiral Chester W. Nimitz, who retired to the Bay Area. The northernmost five miles (8.0 km) is also commonly referred to as the Cypress Freeway, after the former alignment of the freeway and its subsequent replacement.