The United States Indian Industrial School in Carlisle, Pennsylvania, generally known as Carlisle Indian Industrial School, was the flagship Indian boarding school in the United States from its founding in 1879 through 1918. It was based in the historic Carlisle Barracks, which was transferred to the Department of Interior from the War Department for the purpose of establishing the school. After the United States entered World War I, however, the school was closed, and the property on which it was located was transferred back for use by the U.S. Department of Defense. The property is now part of the U.S. Army War College.

Carlisle is a borough in and the county seat of Cumberland County, Pennsylvania, United States. Carlisle is located within the Cumberland Valley, a highly productive agricultural region. As of the 2020 census, the borough population was 20,118; including suburbs in the neighboring townships, 37,695 live in the Carlisle urban cluster. Carlisle is the smaller principal city of the Harrisburg–Carlisle metropolitan statistical area, which includes Cumberland and Dauphin and Perry counties in South Central Pennsylvania.