Case Western Reserve University (CWRU) is a private research university in Cleveland, Ohio. Case Western Reserve was established after Western Reserve University—which was founded in 1826 and named for its location in the Connecticut Western Reserve—and Case Institute of Technology—which was founded in 1880 through the endowment of Leonard Case Jr.—formally federated in 1967.

Cleveland, officially the City of Cleveland, is a city in the U.S. state of Ohio and the county seat of Cuyahoga County. Located in Northeast Ohio along the southern shore of Lake Erie, it is situated across the U.S. maritime border with Canada and lies approximately 60 miles (97 km) west of Pennsylvania. Cleveland ranks as the most populous city on Lake Erie, the second-most populous city in Ohio, and the 54th-most populous city in the U.S. with a 2020 population of 372,624. The city anchors the Cleveland metropolitan area, the 33rd-largest in the U.S. at 2.18 million residents, as well as the larger Cleveland–Akron–Canton combined statistical area, the most populous in Ohio and the 17th-largest in the country with a population of 3.63 million in 2020.