The Chenango Canal was a towpath canal in central New York in the United States which linked the Susquehanna River to the Erie Canal. Built and operated in the mid-19th century, it was 97 miles long and for much of its course followed the Chenango River, along New York State Route 12 from Binghamton on the south end to Utica on the north. It operated from 1834 to 1878 and provided a significant link in the water transportation system of the northeastern U.S. until supplanted by the region's developing railroad network.

The Susquehanna River is a major river located in the Mid-Atlantic region of the United States, overlapping between the lower Northeast. At 444 miles (715 km) long, it is the longest river on the East Coast of the United States. By watershed area, it is the 16th-largest river in the United States, and also the longest river in the early 21st-century continental United States without commercial boat traffic.