Colombia competed at the 2016 Summer Olympics in Rio de Janeiro, Brazil, from 5 to 21 August 2016. This was the nation's nineteenth appearance at the Summer Olympics. The Colombian Olympic Committee sent the nation's largest ever delegation to the Games, with 147 athletes, 74 men and 73 women, competing across 23 sports.

The Men's 69 kg weightlifting competitions at the 2016 Summer Olympics in Rio de Janeiro took place on 9 August at the Pavilion 2 of Riocentro.