Colonization of the Moon is a process or concept employed by some proposals for robotic or human exploitation and settlement endeavours on the Moon. Settling of the Moon is, therefore, a more specific concept of lunar habitation, for which the broader concept of colonization is often used as a synonym, a use that is contested in the light of colonialism.

The Moon bears substantial natural resources which could be exploited in the future. Potential lunar resources may encompass processable materials such as volatiles and minerals, along with geologic structures such as lava tubes that, together, might enable lunar habitation. The use of resources on the Moon may provide a means of reducing the cost and risk of lunar exploration and beyond.