The Cross Bronx Expressway is a major freeway in the New York City borough of the Bronx. It is mainly designated as part of Interstate 95 (I-95), but also includes portions of I-295 and U.S. Route 1 (US 1). The Cross Bronx begins at the eastern approach to the Alexander Hamilton Bridge over the Harlem River. While I-95 leaves at the Bruckner Interchange in Throgs Neck, following the Bruckner Expressway and New England Thruway to Connecticut, the Cross Bronx Expressway continues east, carrying I-295 to the merge with the Throgs Neck Expressway near the Throgs Neck Bridge. Though the road goes primarily northwest-to-southeast, the nominal directions of all route numbers west of the Bruckner Interchange are aligned with the northbound route number going southeast, and the southbound route number going northwest.

The Bronx is a borough of New York City, coextensive with Bronx County, in the U.S. state of New York. It is south of Westchester County; north and east of the New York City borough of Manhattan, across the Harlem River; and north of the New York City borough of Queens, across the East River. The Bronx is the only New York City borough not primarily located on an island. The Bronx has a land area of 42 square miles (109 km2) and a population of 1,472,654 in the 2020 census. If each borough were ranked as a city, the Bronx would rank as the ninth-most-populous in the U.S. Of the five boroughs, it has the fourth-largest area, fourth-highest population, and third-highest population density. The population density of the Bronx was 32,718.7 inhabitants per square mile (12,632.8/km2) in 2022, the third-highest population density of any county in the United States, behind Manhattan and Brooklyn. With a population that is 54.8% Hispanic as of 2020, it is the only majority-Hispanic county in the Northeastern United States and the fourth-most-populous nationwide.