"Cross Road Blues" is a song written by the American blues artist Robert Johnson. He performed it solo with his vocal and acoustic slide guitar in the Delta blues style. The song has become part of the Robert Johnson mythology as referring to the place where he sold his soul to the Devil in exchange for musical genius. This is based largely on folklore of the American South that identifies a crossroads as the site where Faustian bargains can be made, as the lyrics do not contain any references to Satan.

Blues is a music genre and musical form that originated amongst African-Americans in the Deep South of the United States around the 1860s. Blues incorporated spirituals, work songs, field hollers, shouts, chants, and rhymed simple narrative ballads from the African-American culture. The blues form is ubiquitous in jazz, rhythm and blues, and rock and roll, and is characterized by the call-and-response pattern, the blues scale, and specific chord progressions, of which the twelve-bar blues is the most common. Blue notes, usually thirds, fifths or sevenths flattened in pitch, are also an essential part of the sound. Blues shuffles or walking bass reinforce the trance-like rhythm and form a repetitive effect known as the groove.