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DNA methylation
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DNA methylation is a biological process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene promoter, DNA methylation typically acts to repress gene transcription. In mammals, DNA methylation is essential for normal development and is associated with a number of key processes including genomic imprinting, X-chromosome inactivation, repression of transposable elements, aging, and carcinogenesis.
Representation of a DNA molecule that is methylated. The two white spheres represent methyl groups. They are bound to two cytosine nucleotide molecule
Representation of a DNA molecule that is methylated. The two white spheres represent methyl groups. They are bound to two cytosine nucleotide molecules that make up the DNA sequence.
Promoter (genetics)
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In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the promoter. The RNA transcript may encode a protein (mRNA), or can have a function in and of itself, such as tRNA or rRNA. Promoters are located near the transcription start sites of genes, upstream on the DNA . Promoters can be about 100–1000 base pairs long, the sequence of which is highly dependent on the gene and product of transcription, type or class of RNA polymerase recruited to the site, and species of organism.
Ten classes of eukaryotic promoters and their representative DNA Patterns. The representative eukaryotic promoter classes are shown in the following s
Ten classes of eukaryotic promoters and their representative DNA Patterns. The representative eukaryotic promoter classes are shown in the following sections: (A) AT-based class, (B) CG-based class, (C) ATCG-compact class, (D) ATCG-balanced class, (E) ATCG-middle class, (F) ATCG-less class, (G) AT-less class, (H) CG-spike class, (I) CG-less class and (J) ATspike class.
Regulation of transcription in mammals. An active enhancer regulatory region is enabled to interact with the promoter region of its target gene by for
Regulation of transcription in mammals. An active enhancer regulatory region is enabled to interact with the promoter region of its target gene by formation of a chromosome loop. This can initiate messenger RNA (mRNA) synthesis by RNA polymerase II (RNAP II) bound to the promoter at the transcription start site of the gene. The loop is stabilized by one architectural protein anchored to the enhancer and one anchored to the promoter and these proteins are joined to form a dimer (red zigzags). Specific regulatory