The Darien scheme was an unsuccessful attempt, backed largely by investors of the Kingdom of Scotland, to gain wealth and influence by establishing New Caledonia, a colony in the Darién Gap on the Isthmus of Panama, in the late 1690s. The plan was for the colony, located on the Gulf of Darién, to establish and manage an overland route to connect the Pacific and Atlantic Oceans. The backers knew that the first sighting of the Pacific Ocean by Balboa was after crossing the isthmus through Darién. The expedition also took sovereignty over 'Crab Isle' in 1698, yet sovereignty was short-lived. The attempt at settling the area did not go well; more than 80 per cent of participants died within a year, and the settlement was abandoned twice.

The Darién Gap is a geographic region that connects the American continents, stretching across southern Panama's Darién Province and the northern portion of Colombia's Chocó Department. Consisting of a large watershed, dense rainforest, and mountains, it is known for its remoteness, difficult terrain, and extreme environment, with a reputation as one of the most inhospitable regions in the world. Nevertheless, as the only land bridge between North and South America, the Darién Gap has historically served as a major route for both humans and wildlife.